ArticleAnimals : an open access journal from MDPI2016
Food Deprivation, Body Weight Loss and Anxiety-Related Behavior in Rats.
Article in Animals : an open access journal from MDPI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Divergent behavioral strategies in Wistar and Wistar-Kyoto rats in a naturalistic task reveal mood disorder phenotypes.iScience · 2026Article
- Preclinic evaluation of the safety of potential anticovid-19 phytomedicine: SAYE PLUS impacts on Wistar rat biochemical and histopathological parameters in sub-chronic toxicity study.BMC pharmacology & toxicology · 2025Article
- In search of prosociality in rodents: A scoping review.PloS one · 2024Article
- Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics.Neurobiology of stress · 2024Article
- Effects of intermittent fasting on the histology and mRNA expression of major drug-metabolizing cyp450s in the liver of diabetic mice.The Libyan journal of medicine · 2023Article
- Article
- Behavioral Paradigm for the Evaluation of Stimulation-Evoked Somatosensory Perception Thresholds in Rats.bioRxiv : the preprint server for biology · 2023Article
- Psychological dominant stressor modification to an animal model of depression with chronic unpredictable mild stress.Veterinary world · 2023Article
- Behavioral paradigm for the evaluation of stimulation-evoked somatosensory perception thresholds in rats.Frontiers in neuroscience · 2023Article
- Maternal neglect alters reward-anticipatory behavior, social status stability, and reward circuit activation in adult male rats.Frontiers in neuroscience · 2023Article
- Pharmacological activation of the amygdala, but not single prolonged footshock-induced acute stress, interferes with cue-induced motivation toward food rewards in rats.Frontiers in behavioral neuroscience · 2023Article
- Body size and brain volumetry in the rat following prolonged morphine administration in infancy and adulthood.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Manifestations of domination: Assessments of social dominance in rodents.Genes, brain, and behavior · 2022Review
- Article
- Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat.Molecular neurobiology · 2021Article
- Sub-chronic dermal exposure to aircraft engine oils impacts the reproductive organ weights and alters hematological profiles of Sprague Dawley rats.Current research in toxicology · 2020Article
- The Impact of Common Recovery Blood Sampling Methods, in Mice (Mus Musculus), on Well-Being and Sample Quality: A Systematic Review.Animals : an open access journal from MDPI · 2020Review
- Palm Weevil Larvae (Journal of nutrition and metabolism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In behavioral studies, food deprivation protocols are routinely used to initiate or maintain motivational states that are required in a particular test situation. However, there is limited evidence as to when food deprivation compromises animal welfare. This study investigated the effects of different lengths of food deprivation periods and restricted (fixed-time) feeding on body weight loss as well as anxiety-related and motivated behavior in 5-6 month old male and female Wistar rats. The observed body weight loss was not influenced by sex and ranged between 4% (16 h deprivation) to approximately 9% (fixed-time feeding). Despite significant body weight loss in all groups, the motivation to eat under the aversive test conditions of the modified open field test increased only after 48 h of food deprivation. Long-lasting effects on anxiety as measured in the elevated plus maze test 24 h after refeeding have not been observed, although fixed-time feeding could possibly lead to a lasting anxiogenic effect in female rats. Overall, female rats showed a more anxiolytic profile in both tests when compared to male rats. Despite these sex differences, results suggest that food deprivation is not always paralleled by an increased motivation to feed in a conflict situation. This is an important finding as it highlights the need for tailored pilot experiments to evaluate the impact of food deprivation protocols on animals in regard to the principles of the 3Rs introduced by Russell and Burch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.