ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 90 citations in OpenAlex.
- Modeling Concurrent Hedonic Disruption During Excessive Drinking and Abstinence-Related Negative Affect in a Novel Selectively Bred Mouse Line: The Crossed High Alcohol Preferring X High Drinking in the Dark (cHAPxHDID) Mice.Alcohol, clinical & experimental research · 2026Article
- Association of stress-sensitive mid-insula activity with alcohol drinking and negative affect-like behavior during abstinence in mice.Neuropharmacology · 2026Article
- Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence.Psychopharmacology · 2026Article
- Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning.Psychopharmacology · 2026Article
- Cholinergic regulation of prolonged alcohol withdrawal differs by sex.bioRxiv : the preprint server for biology · 2025Article
- Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner.Addiction neuroscience · 2025Article
- Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review.Alcohol, clinical & experimental research · 2025Review
- Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking.Nature communications · 2025Article
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation.Frontiers in pharmacology · 2025Article
- Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion.Alcohol (Fayetteville, N.Y.) · 2024Review
- Sex differences in basal motivated behavior, chronic ethanol drinking, and amygdala activity in female and male mice.Alcohol (Fayetteville, N.Y.) · 2024Article
- BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.Alcohol, clinical & experimental research · 2024Article
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Home cage voluntary alcohol consumption increases binge drinking without affecting abstinence-related depressive-like behaviors or operant responding in crossed high alcohol-preferring mice (cHAPs).Alcohol (Fayetteville, N.Y.) · 2024Article
- Sex-specific negative affect-like behaviour and parabrachial nucleus activation induced by BNST stimulation in adult mice with adolescent alcohol history.Addiction biology · 2024Article
- Forced Abstinence from Volitional Ethanol Intake Drives a Vulnerable Period of Hyperexcitability in BNST-Projecting Insular Cortex Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice.Biology of sex differences · 2023Article
- A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice.Neuropharmacology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Although alcoholism and depression are highly comorbid, treatment options that take this into account are lacking, and mouse models of alcohol (ethanol (EtOH)) intake-induced depressive-like behavior have not been well established. Recent studies utilizing contingent EtOH administration through prolonged two-bottle choice access have demonstrated depression-like behavior following EtOH abstinence in singly housed female C57BL/6J mice. In the present study, we found that depression-like behavior in the forced swim test (FST) is revealed only after a protracted (2 weeks), but not acute (24 h), abstinence period. No effect on anxiety-like behavior in the EPM was observed. Further, we found that, once established, the affective disturbance is long-lasting, as we observed significantly enhanced latencies to approach food even 35 days after ethanol withdrawal in the novelty-suppressed feeding test (NSFT). We were able to reverse affective disturbances measured in the NSFT following EtOH abstinence utilizing the N-methyl D-aspartate receptor (NMDAR) antagonist and antidepressant ketamine but not memantine, another NMDAR antagonist. Pretreatment with the monoacylglycerol (MAG) lipase inhibitor JZL-184 also reduced affective disturbances in the NSFT in ethanol withdrawn mice, and this effect was prevented by co-administration of the CB1 inverse agonist rimonabant. Endocannabinoid levels were decreased within the BLA during abstinence compared with during drinking. Finally, we demonstrate that the depressive behaviors observed do not require a sucrose fade and that this drinking paradigm may favor the development of habit-like EtOH consumption. These data could set the stage for developing novel treatment approaches for alcohol-withdrawal-induced mood and anxiety disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.