Evidence map›Paper›PMID 26751119›Full record

ArticleNeurobiology of stress2016

Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats.

D P Holschneider, Y Guo, E A Mayer, Z Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Neural circuits regulating visceral pain.Communications biology · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Gabapentin Improves Oral Feeding in Neurologically Intact Infants With Abdominal Disorders.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

D P HolschneiderDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA; Departments of Neurology, Cell and Neurobiology, Biomedical Engineering, University of Southern California, Los Angeles, CA, USA; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Y GuoDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
E A MayerVeterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, United States of America; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA; Departments of Physiology, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Z WangDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
University of Southern California · USNeurobehavioral Systems · USUniversity of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
NIDDK NIH HHS P30 DK041301NIDDK NIH HHS P50 DK064539
6 · The paper itself

Abstract

Early life stress (ELS) is a risk factor for developing functional gastrointestinal disorders, and has been proposed to be related to a central amplification of sensory input and resultant visceral hyperalgesia. We sought to characterize ELS-related changes in functional brain responses during acute noxious visceral stimulation. Neonatal rats (males/females) were exposed to limited bedding (ELS) or standard bedding (controls) on postnatal days 2-9. Age 10-11 weeks, animals were implanted with venous cannulas and transmitters for abdominal electromyography (EMG). Cerebral blood flow (rCBF) was mapped during colorectal distension (CRD) using [

Indexed as

brain mappingearly life stressnesting behaviornociceptionsex differencesvisceral pain

Identifiers

PMID26751119
PMCPMC4700548
OpenAlexW2237618756

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.