ArticlePloS one2016
Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Pericarotid fat density: a novel predictor of cognitive and functional outcomes in cerebral small vessel disease.Frontiers in aging neuroscience · 2026Article
- Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding.Journal of Alzheimer's disease : JAD · 2025Article
- Cerebral Hemodynamic Impairment and Cognitive Dysfunction inJournal of the American Heart Association · 2025Observational
- Influencing factors and predictive models of early post-stroke depression in patients with acute ischemic stroke.BMC neurology · 2025Article
- Risk of Stroke or Heart Attack in Mild Cognitive Impairment and Subjective Cognitive Impairment.Neurology international · 2024Article
- NO Deficiency Compromises Inter- and Intrahemispheric Blood Flow Adaptation to Unilateral Carotid Artery Occlusion.International journal of molecular sciences · 2024Article
- Effects of physical activity breaks during prolonged sitting on vascular and executive function-A randomised cross-over trial.Journal of Taibah University Medical Sciences · 2023Article
- Article
- Examination of brain area volumes based on voxel-based morphometry and multidomain cognitive impairment in asymptomatic unilateral carotid artery stenosis.Frontiers in aging neuroscience · 2023Article
- Association between serum cystatin C level and post-stroke cognitive impairment in patients with acute mild ischemic stroke.Brain and behavior · 2022Article
- A model to predict unstable carotid plaques in population with high risk of stroke.BMC cardiovascular disorders · 2020Article
- A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- In-stent restenosis associated with dual-layer Roadsaver carotid artery stent: a retrospective single-center study.La Radiologia medica · 2019Article
- Cognitive impairment and sleep disturbances after minor ischemic stroke.Sleep & breathing = Schlaf & Atmung · 2019Observational
- Association between Carotid Plaque and Cognitive Impairment in Chinese Stroke Population: The SOS-Stroke Study.Scientific reports · 2017Article
- Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment.Brain and behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate potential associations between carotid artery stenosis and cognitive impairment among patients with acute ischemic stroke and to provide important clinical implications. We measured the degree of carotid artery stenosis and recorded the Mini-Mental State Examination score (MMSE) at admission in 3116 acute ischemic stroke patients. The association between carotid stenosis and cognitive impairment assessed by MMSE was tested using multivariate regression analysis. Other clinical variables of interest were also studied. After adjusting for age, gender, education level, marriage, alcohol use, tobacco use, physical activity, hypertension, diabetes, hypercholesterolemia, atrial fibrillation, myocardial infarction and NIHSS (National Institutes of Health Stroke Scale) score, we found that participants with high-grade stenosis of the carotid artery had a higher likelihood of cognitive impairment compared to those without carotid artery stenosis (OR = 1.49, 95%CI: 1.05-2.11, p<0.001). Left common carotid artery stenosis was associated with cognitive impairment in the univariate analysis, although this effect did not persist after adjustment for the NIHSS score. Cognitive impairment was associated with high-grade stenosis of the right carotid artery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.