Evidence map›Paper›PMID 26751031›Full record

ArticleJournal of global infectious diseases

Identification of Invasive Salmonella Enterica Serovar Typhimurium ST313 in Ambulatory HIV-Infected Adults in Mozambique.

Troy D Moon, Monika Johnson, Monique A Foster, Wilson P Silva, Manuel Buene, Emilio Valverde, Luís Morais, John V Williams, Sten H Vermund, Paula E Brentlinger

Open access · goldAbstract read
In one paragraph

Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Multidrug-resistant Nontyphoidal Salmonella Hotspots as Targets for Vaccine Use in Management of Infections in Endemic Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  5. Current perspectives on invasive nontyphoidal Salmonella disease.Current opinion in infectious diseases · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Troy D MoonVanderbilt Institute for Global Health, Vanderbilt University, Nashville; Department of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical School, Nashville, Tennessee, United States; Friends in Global Health, Maputo, Mozambique.
Monika JohnsonDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical School, Nashville, Tennessee, United States.
Monique A FosterDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical School, Nashville, Tennessee, United States.
Wilson P SilvaFriends in Global Health, Maputo, Mozambique; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, United States.
Manuel BueneFriends in Global Health, Maputo, Mozambique.
Emilio ValverdeFriends in Global Health, Maputo, Mozambique; Department of Health Policy, Vanderbilt University Medical School, Nashville, Tennessee, United States.
Luís MoraisFriends in Global Health, Maputo, Mozambique.
John V WilliamsDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical School, Nashville, Tennessee, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, United States.
Sten H VermundVanderbilt Institute for Global Health, Vanderbilt University, Nashville; Department of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical School, Nashville, Tennessee, United States; Friends in Global Health, Maputo, Mozambique.
Paula E BrentlingerFriends in Global Health, Maputo, Mozambique.
Vanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Vanderbilt Rural Mozambique Project: Proposal for PEPFAR-Supported Care and TreatU2GPS000631 · PS · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2012
$40.2M
NCATS NIH HHS UL1 TR000445NCHHSTP CDC HHS U2G PS000631
6 · The paper itself

Abstract

introductionDespite evidence describing the burden of invasive non-typhoidal salmonella (iNTS) disease in sub-Saharan Africa, iNTS is not recognized as a priority within global health policy institutions. Recently, Salmonella enterica serovar Typhimurium, sequence type (ST) 313, has been identified as the predominant cause of iNTS disease in multiple sub-Saharan African countries. MATERIALS AND

methodsWe conducted multilocus sequence typing (MLST) to determine the prevalence of the ST313 genotype in a sample of blood isolates from ambulatory HIV-infected Mozambican adults with iNTS disease.

resultsOf the 29 samples of NTS obtained and analyzed by MLST, all (29/29) were assigned the ST313 sequence type based on the set of allele types derived from each of the seven loci. For quality control, five randomly selected strains taken from the original cultures were confirmed as ST313, and the positive control strain SL3261 (taken from the original culture) was categorized as S. Typhimurium ST19.

conclusionS. Typhimurium ST313 is an important example of a widely distributed pathogen that lacks a coordinated strategy for control. The highly vulnerable populations at risk for ST313 infection in Mozambique, and within the region, would benefit greatly from the development of new policy and on-the-ground capacity to support increased surveillance, prevention, and treatment initiatives.

Indexed as

AfricaHuman immunodeficiency virusInvasive non-typhoidal salmonellaSalmonella Typhimurium ST313

Identifiers

PMID26751031
PMCPMC4693304
OpenAlexW2282079183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.