Evidence map›Paper›PMID 26750864›Full record

ReviewTrends in parasitology2016

Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors.

Martin J Donnelly, Alison T Isaacs, David Weetman

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
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  15. Field-evolved resistance to neonicotinoids in the mosquito,bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Discovery of knock-down resistance in the major African malaria vectorbioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martin J DonnellyDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK; Malaria Programme, Wellcome Trust Sanger Institute, Cambridge, UK. Electronic address: martin.donnelly@lstmed.ac.uk.
Alison T IsaacsDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
David WeetmanDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2010 to 2026
$29.3M
NIAID NIH HHS U19 AI089674NIAID NIH HHS U19AI089674
6 · The paper itself

Abstract

Insecticide resistance is a major obstacle to control of Anopheles malaria mosquitoes in sub-Saharan Africa and requires an improved understanding of the underlying mechanisms. Efforts to discover resistance genes and DNA markers have been dominated by candidate gene and quantitative trait locus studies of laboratory strains, but with greater availability of genome sequences a shift toward field-based agnostic discovery is anticipated. Mechanisms evolve continually to produce elevated resistance yielding multiplicative diagnostic markers, co-screening of which can give high predictive value. With a shift toward prospective analyses, identification and screening of resistance marker panels will boost monitoring and programmatic decision making.

Indexed as

AnimalsAnophelesCytochrome P-450 Enzyme SystemGenetic MarkersGenome, InsectGenomicsInsecticide ResistanceInsect VectorsMolecular Diagnostic TechniquesParasitologyCytochrome P-450 Enzyme SystemGenetic Markers

Identifiers

PMID26750864
PMCPMC4767538

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.