ArticleScientific reports2016
Leucine zipper motif in RRS1 is crucial for the regulation of Arabidopsis dual resistance protein complex RPS4/RRS1.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- A modular fragment of Arabidopsis cation exchanger 1 (CAX1) reveals structural constraints on assembly.Plant molecular biology · 2025Article
- WRKY transcription factors participate in abiotic stress responses mediated by sugar metabolism.Frontiers in plant science · 2025Review
- An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana.PLoS genetics · 2023Article
- The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions.PLoS genetics · 2017Article
- DES-TOMATO: A Knowledge Exploration System Focused On Tomato Species.Scientific reports · 2017Article
- Analyses of natural variation indicates that the absence of RPS4/RRS1 and amino acid change in RPS4 cause loss of their functions and resistance to pathogens.Plant signaling & behavior · 2017Article
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Authors and funding
7 authors at 4 institutions in 1 country.
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Abstract
Arabidopsis thaliana leucine-rich repeat-containing (NLR) proteins RPS4 and RRS1, known as dual resistance proteins, confer resistance to multiple pathogen isolates, such as the bacterial pathogens Pseudomonas syringae and Ralstonia solanacearum and the fungal pathogen Colletotrichum higginsianum. RPS4 is a typical Toll/interleukin 1 Receptor (TIR)-type NLR, whereas RRS1 is an atypical TIR-NLR that contains a leucine zipper (LZ) motif and a C-terminal WRKY domain. RPS4 and RRS1 are localised near each other in a head-to-head orientation. In this study, direct mutagenesis of the C-terminal LZ motif in RRS1 caused an autoimmune response and stunting in the mutant. Co-immunoprecipitation analysis indicated that full-length RPS4 and RRS1 are physically associated with one another. Furthermore, virus-induced gene silencing experiments showed that hypersensitive-like cell death triggered by RPS4/LZ motif-mutated RRS1 depends on EDS1. In conclusion, we suggest that the RRS1-LZ motif is crucial for the regulation of the RPS4/RRS1 complex.
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