Evidence map›Paper›PMID 26750579›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016

Tongue electrical impedance in amyotrophic lateral sclerosis modeled using the finite element method.

Adam Pacheck, Alex Mijailovic, Sung Yim, Jia Li, Jordan R Green, Courtney E McIlduff, Seward B Rutkove

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06491732 (Electrical Impedance Myography Via the Myolex mScan as an ALS Biomarker), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06491732 recruitingnot on this mapstarted 2025, after this paper: background citation

Electrical Impedance Myography Via the Myolex mScan as an ALS Biomarker

TypeobservationalSponsorBeth Israel Deaconess Medical CenterRan2025 to 2027Enrolled80ConditionsAmyotrophic Lateral SclerosisArmsElectrical Impedance Myography
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adam PacheckDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Alex MijailovicDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Sung YimDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jia LiDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jordan R GreenMGH Institute of Health Professions, Boston, MA 02129, USA.
Courtney E McIlduffDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: srutkove@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · USMGH Institute of Health Professions · US

Funding

Electrical Impedance Myography in an Animal ModelR01NS055099 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2007 to 2022
$5.1M
Innovative Ultrasound Technology in Neuromuscular DiseaseK24NS060951 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2008 to 2017
$1.5M
NINDS NIH HHS K24 NS060951NINDS NIH HHS K24NS060951NINDS NIH HHS R01 NS055099
6 · The paper itself

Abstract

objectiveElectrical impedance myography (EIM) of the tongue has demonstrated alterations in patients with amyotrophic lateral sclerosis (ALS) compared to normal subjects. Whether these differences are due to reduced tongue size or diseased-associated alterations in the electrical characteristics of intrinsic tongue muscles is uncertain.

methodsWe employed computer simulations using the finite element method, inputting data from healthy and ALS mouse muscle, to help answer that question, comparing our modeled results to human data.

resultsThe models revealed that much of the electrical current flows superficially in the tongue and that tongue thickness only begins to have a major impact on the measured impedance when substantial atrophy is present. Modeled values paralleled the human tongue data.

conclusionsThese findings suggest that the observed changes in tongue impedance in ALS are mainly due to alterations in the electrical properties of the tongue and are not a mere consequence of tongue volume loss. SIGNIFICANCE: Further development of EIM for evaluation of bulbar dysfunction in ALS may provide useful information on drug efficacy and could serve as a biomarker in future clinical trials.

Indexed as

Finite Element AnalysisModels, BiologicalAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAnimalsElectric ImpedanceFemaleHumansMaleMiceMiddle AgedTongueYoung AdultAmyotrophic lateral sclerosisAtrophyElectrical impedanceModelingTongue

Identifiers

PMID26750579
PMCPMC4828196
OpenAlexW2191367379

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.