ArticleGenes, brain, and behavior2016
The D1 family dopamine receptor, DopR, potentiates hind leg grooming behavior in Drosophila.
Article in Genes, brain, and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Behavior choices amongst grooming, feeding and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs.The Journal of experimental biology · 2025Article
- Real-Time Recognition and Detection ofSensors (Basel, Switzerland) · 2023Article
- Parasitoid wasp venom re-programs host behavior through downmodulation of brain central complex activity and motor output.The Journal of experimental biology · 2023Article
- Parasitoid wasp venom manipulates host innate behavior via subtype-specific dopamine receptor activation.The Journal of experimental biology · 2022Article
- Article
- A Method to QuantifyBio-protocol · 2021Article
- Exposure to bisphenol A differentially impacts neurodevelopment and behavior in Drosophila melanogaster from distinct genetic backgrounds.Neurotoxicology · 2021Article
- Genetic Basis of Natural Variation in Spontaneous Grooming inG3 (Bethesda, Md.) · 2020Article
- Come Fly with Me: An overview of dopamine receptors in Drosophila melanogaster.Basic & clinical pharmacology & toxicology · 2020Review
- Anti-instinctive Learning Behavior Revealed by Locomotion-Triggered Mild Heat Stress inFrontiers in behavioral neuroscience · 2020Article
- Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons inFrontiers in systems neuroscience · 2018Article
- Pharmacochaperoning in aThe Journal of biological chemistry · 2017Article
- Quantification of Drosophila Grooming Behavior.Journal of visualized experiments : JoVE · 2017Article
- Fly Stampede 2.0: A Next Generation Optomotor Assay for Walking Behavior inFrontiers in molecular neuroscience · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila groom away debris and pathogens from the body using their legs in a stereotyped sequence of innate motor behaviors. Here, we investigated one aspect of the grooming repertoire by characterizing the D1 family dopamine receptor, DopR. Removal of DopR results in decreased hind leg grooming, as substantiated by quantitation of dye remaining on mutant and RNAi animals vs. controls and direct scoring of behavioral events. These data are also supported by pharmacological results that D1 receptor agonists fail to potentiate grooming behaviors in headless DopR flies. DopR protein is broadly expressed in the neuropil of the thoracic ganglion and overlaps with TH-positive dopaminergic neurons. Broad neuronal expression of dopamine receptor in mutant animals restored normal grooming behaviors. These data provide evidence for the role of DopR in potentiating hind leg grooming behaviors in the thoracic ganglion of adult Drosophila. This is a remarkable juxtaposition to the considerable role of D1 family dopamine receptors in rodent grooming, and future investigations of evolutionary relationships of circuitry may be warranted.
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