ArticleAmerican journal of human genetics2016
Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice.
Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Molecular assessment of recombination processing across genetically diverse mouse strains reveals sexually dimorphic determinants of crossover distribution beyond chromosome length.Molecular biology and evolution · 2026Article
- Meiotic Recombination in Teleosts.Advances in experimental medicine and biology · 2026Review
- Chromosome length is not the sole determinant of sexually dimorphic crossover rates during mammalian meiosis: Insights from genetically diverse mouse strains.bioRxiv : the preprint server for biology · 2025Article
- Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.Environmental health perspectives · 2025Article
- The RING Domain of Rice HEI10 is Essential for Male, But Not Female Fertility.Rice (New York, N.Y.) · 2024Article
- Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone.Scientific reports · 2022Article
- Two telomeric ends of acrocentric chromosome play distinct roles in homologous chromosome synapsis in the fetal mouse oocyte.Chromosoma · 2021Article
- Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.Frontiers in cell and developmental biology · 2021Article
- Meiotic Chromosome Dynamics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Article
- Sex Differences in the Recombination Landscape.The American naturalist · 2020Article
- WOMEN IN REPRODUCTIVE SCIENCE: Errors and insight: intentional and accidental studies of human chromosome abnormalities.Reproduction (Cambridge, England) · 2019Review
- Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm.Science (New York, N.Y.) · 2019Article
- Connecting theory and data to understand recombination rate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Age-Related Loss of Cohesion: Causes and Effects.International journal of molecular sciences · 2017Review
- Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia.Cell proliferation · 2017Article
- Evolutionary mysteries in meiosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Crossover patterns under meiotic chromosome program.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Meiotic recombination is initiated by programmed double strand breaks (DSBs), only a small subset of which are resolved into crossovers (COs). The mechanism determining the location of these COs is not well understood. Studies in plants, fungi, and insects indicate that the same genomic regions are involved in synaptic initiation and COs, suggesting that early homolog alignment is correlated with the eventual resolution of DSBs as COs. It is generally assumed that this relationship extends to mammals, but little effort has been made to test this idea. Accordingly, we conducted an analysis of synaptic initiation sites (SISs) and COs in human and mouse spermatocytes and oocytes. In contrast to our expectation, we observed remarkable sex- and species-specific differences, including pronounced differences between human males and females in both the number and chromosomal location of SISs. Further, the combined data from our studies in mice and humans suggest that the relationship between SISs and COs in mammals is a complex one that is not dictated by the sites of synaptic initiation as reported in other organisms, although it is clearly influenced by them.
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Registered trials
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