ArticleClinical therapeutics2016
Association of Lower Socioeconomic Position in Pregnancy with Lower Diurnal Cortisol Production and Lower Birthweight in Male Infants.
Article in Clinical therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study.RMD open · 2023Observational
- Maternal Diet Quality and Prenatal Depressive Symptoms: The Moderating Role of Economic Well-Being.Nutrients · 2023Article
- Sex Differences Are Here to Stay: Relevance to Prenatal Care.Journal of clinical medicine · 2021Review
- Maternal Prenatal Cortisol and Breastfeeding Predict Infant Growth.International journal of environmental research and public health · 2020Article
- Maternal History of Adverse Childhood Experiences and Ambulatory Blood Pressure in Pregnancy.Psychosomatic medicine · 2020Article
- Prenatal Maternal Cortisol Levels and Infant Birth Weight in a Predominately Low-Income Hispanic Cohort.International journal of environmental research and public health · 2020Article
- Prenatal socioeconomic status and social support are associated with neonatal brain morphology, toddler language and psychiatric symptoms.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Observational
- Repetitive negative thinking, meaning in life, and serum cytokine levels in pregnant women: varying associations by socioeconomic status.Journal of behavioral medicine · 2019Article
- The Effect of Prenatal Stress, Proxied by Marital and Paternity Status, on the Risk of Preterm Birth.International journal of environmental research and public health · 2019Article
- Maternal Lifetime Trauma and Birthweight: Effect Modification by In Utero Cortisol and Child Sex.The Journal of pediatrics · 2018Article
- Impact of prenatal stress on mother-infant dyadic behavior during the still-face paradigm.Borderline personality disorder and emotion dysregulation · 2018Article
- Impact of prenatal stress on the dyadic behavior of mothers and their 6-month-old infants during a play situation: role of different dimensions of stress.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeLow maternal socioeconomic position (SEP) has been associated with adverse neonatal outcomes, including preterm birth, low birthweight, intrauterine growth restriction, and infant mortality. A key biological mechanism that has been proposed to explain this association is hypothalamic-pituitary-adrenal (HPA) activity, yet the association between SEP and HPA activity in pregnancy has received little attention. In this study we aimed to examine the associations between SEP and 2 forms of maternal cortisol regulation-diurnal slope and wakening response-across pregnancy. Furthermore, we aimed to assess whether these associations differed by the sex of the fetus.
methodsA total of 217 pregnant women aged 18 to 40 years with singleton pregnancies participated. Women were excluded from participating if they were aged <18 or >40 years and if they were at risk for maternal or obstetric complications. Women provided information on socioeconomic characteristics of adults contributing to the participants' household to compute a Hollingshead Four Factor Index of Social Status score of SEP. Women provided salivary cortisol samples on awakening, 30 minutes after wakeup, and at bedtime, at 3 times over pregnancy and once 30 days postpartum to calculate the diurnal slope and cortisol awakening response (CAR). Using linear regression analyses, we examined the relationships between maternal SEP and maternal diurnal slope and CAR. We explored the relationships between maternal SEP and cortisol by fetal sex using linear regression analyses. We also explored links between maternal SEP, maternal cortisol, and infant birth outcomes.
findingsWomen of lower SEP displayed smaller awakening responses and less change over the day compared with women of higher SEP. SEP was significantly associated with attenuated diurnal slope only among women carrying female fetuses, whereas for CAR, the association between SEP and attenuated CAR was significant only for women carrying male fetuses. Lower SEP was associated with decreased birthweight, and this association was partially explained by maternal HPA activity in pregnancy. IMPLICATIONS: Women of low SEP displayed attenuated HPA activity across the perinatal period, and patterns varied by fetal sex and cortisol metric. Findings are in need of replication. More research is needed to understand the links between SEP, HPA activity, and neonatal health.
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