ArticleMolecular ecology2016
Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks.
Article in Molecular ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes.Molecular biology and evolution · 2026Article
- The interplay between epigenomic and transcriptomic variation during ecotype divergence in stickleback.BMC biology · 2025Article
- Assessing Mechanisms of Potential Local Adaptation Through a Seascape Genomic Approach in a Marine Gastropod, Littoraria flava.Genome biology and evolution · 2024Article
- Pleiotropy facilitates parallel adaptation in sticklebacks.Molecular ecology · 2022Article
- Cross-continental experimental infections reveal distinct defence mechanisms in populations of the three-spined sticklebackProceedings. Biological sciences · 2021Article
- Article
- Article
- Gene expression response to a nematode parasite in novel and native eel hosts.Ecology and evolution · 2019Article
- Transferrin Identification in Sterlet (Animals : an open access journal from MDPI · 2019Article
- Genome-Wide Genotype-Expression Relationships Reveal Both Copy Number and Single Nucleotide Differentiation Contribute to Differential Gene Expression between Stickleback Ecotypes.Genome biology and evolution · 2019Article
- Characterization and analysis of the transcriptome in Gymnocypris selincuoensis on the Qinghai-Tibetan Plateau using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Divergent transcriptomic signatures in response to salinity exposure in two populations of an estuarine fish.Evolutionary applications · 2019Article
- The right response at the right time: Exploring helminth immune modulation in sticklebacks by experimental coinfection.Molecular ecology · 2019Article
- Specificity of resistance and geographic patterns of virulence in a vertebrate host-parasite system.BMC evolutionary biology · 2019Article
- Cluster expansion of apolipoprotein D (ApoD) genes in teleost fishes.BMC evolutionary biology · 2019Article
- Muscle transcriptome resource for growth, lipid metabolism and immune system in Hilsa shad, Tenualosa ilisha.Genes & genomics · 2019Article
- Multiple Selection Signatures in Farmed Atlantic Salmon Adapted to Different Environments Across Hemispheres.Frontiers in genetics · 2019Article
- Concordant Changes in Gene Expression and Nucleotides Underlie Independent Adaptation to Hydrogen-Sulfide-Rich Environments.Genome biology and evolution · 2018Article
- Convergent evolution of gene expression in two high-toothed stickleback populations.PLoS genetics · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The observation of habitat-specific phenotypes suggests the action of natural selection. The three-spined stickleback (Gasterosteus aculeatus) has repeatedly colonized and adapted to diverse freshwater habitats across the northern hemisphere since the last glaciation, while giving rise to recurring phenotypes associated with specific habitats. Parapatric lake and river populations of sticklebacks harbour distinct parasite communities, a factor proposed to contribute to adaptive differentiation between these ecotypes. However, little is known about the transcriptional response to the distinct parasite pressure of those fish in a natural setting. Here, we sampled wild-caught sticklebacks across four geographical locations from lake and river habitats differing in their parasite load. We compared gene expression profiles between lake and river populations using 77 whole-transcriptome libraries from two immune-relevant tissues, the head kidney and the spleen. Differential expression analyses revealed 139 genes with habitat-specific expression patterns across the sampled population pairs. Among the 139 differentially expressed genes, eight are annotated with an immune function and 42 have been identified as differentially expressed in previous experimental studies in which fish have been immune challenged. Together, these findings reinforce the hypothesis that parasites contribute to adaptation of sticklebacks in lake and river habitats.
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