Evidence map›Paper›PMID 26748883›Full record

Trial reportJournal of traumatic stress2016

5-Hz Transcranial Magnetic Stimulation for Comorbid Posttraumatic Stress Disorder and Major Depression.

Noah S Philip, Samuel J Ridout, Sarah E Albright, George Sanchez, Linda L Carpenter

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traumatic stress, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03840369 (Pathophysiological Understanding and Treatment of PTSD), which is not on this map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03840369 nacompletednot on this mapstarted 2020, after this paper: background citation

Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2022Enrolled25ConditionsStress Disorders, Post-Traumatic, Brain Injuries, Transcranial Magnetic Stimulation, Magnetic Resonance SpectroscopyArmsRepetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex, Sham Repetitive Transcranial Magnetic Stimulation, Repetitive Transcranial Magnetic Stimulation to Right Dorsomedial Prefrontal Cortex
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  5. Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noah S PhilipCenter for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, Rhode Island, USA.
Samuel J RidoutLaboratory for Clinical and Translational Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Sarah E AlbrightCenter for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, Rhode Island, USA.
George SanchezCenter for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, Rhode Island, USA.
Linda L CarpenterLaboratory for Clinical and Translational Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Funding

Promoting Research Training During Psychiatry ResidencyR25MH101076 · NIMH · BROWN UNIVERSITY · PI AUDREY TYRKA · 2013 to 2026
$2.8M
PTSD and the Default Network: Developing Imaging PhenotypesIK2CX000724 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2013 to 2017
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CSRD VA IK2 CX000724NIMH NIH HHS R25 MH101076PHS HHS NIMH R25MH101076
6 · The paper itself

Abstract

Current treatment options for posttraumatic stress disorder (PTSD) offer modest benefits, underscoring the need for new treatments. Repetitive transcranial magnetic stimulation (rTMS) depolarizes neurons in a targeted brain region with magnetic fields typically pulsed at low (1 Hz) or high (10 Hz) frequency to relieve major depressive disorder (MDD). Prior work suggests an intermediate pulse frequency, 5 Hz, is also efficacious for treating comorbid depressive and anxiety symptoms. In this chart review study, we systematically examined the clinical and safety outcomes in 10 patients with comorbid MDD and PTSD syndromes who received 5-Hz rTMS therapy at the Providence VA Medical Center Neuromodulation Clinic. Self-report scales measured illness severity prior to treatment, after every 5 treatments, and upon completion of treatment. Results showed significant reduction in symptoms of PTSD (p = .003, effect size = 1.12, 8/10 with reliable change) and MDD (p = .005, effect size = 1.09, 6/10 with reliable change). Stimulation was well tolerated and there were no serious adverse events. These data indicate 5-Hz rTMS may be a useful option to treat these comorbid disorders. Larger, controlled trials are needed to confirm the benefits of 5-Hz protocols observed in this pilot study.

Indexed as

AdultAnxiety DisordersFemaleHumansMajor Depressive DisorderMaleMiddle AgedSelf ReportSeverity of Illness IndexStress Disorders, Post-TraumaticTranscranial Direct Current StimulationTreatment OutcomeVeterans

Identifiers

PMID26748883
PMCPMC4849266

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.