ReviewAnnals of the New York Academy of Sciences2016
Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Article
- Hematopoietic Stem and Progenitor Cells Establish Dynamic Podosome-Like Structures to Interact with Fibronectin.Advanced biology · 2026Article
- Transcriptional landscape of direct reprogramming toward the hematopoietic lineage.bioRxiv : the preprint server for biology · 2026Article
- Efficient chemical reprogramming of human T cells into functional megakaryocytes and platelets.Science advances · 2026Article
- Bioactive materials forBioactive materials · 2024Review
- Impaired differentiation potential of CD34-positive cells derived from mouse hair follicles after long-term culture.Scientific reports · 2022Article
- Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment.Annals of the New York Academy of Sciences · 2020Review
- Clones assemble! The clonal complexity of blood during ontogeny and disease.Experimental hematology · 2020Review
- Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.FEBS letters · 2019Article
- IRF2 is a master regulator of human keratinocyte stem cell fate.Nature communications · 2019Article
- Article
- CD34+ cells from dental pulp stem cells with a ZFN-mediated and homology-driven repair-mediated locus-specific knock-in of an artificial β-globin gene.Gene therapy · 2017Article
- Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds.Scientific reports · 2017Article
- Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype.Cell reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Even though all paradigms of stem cell therapy and regenerative medicine emerged from the study of hematopoietic stem cells (HSCs), the inability to generate these cells de novo or expand them in vitro persists. Initial efforts to obtain these cells began with the use of embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technologies, but these strategies have yet to yield fully functional cells. Subsequently, more recent approaches involve transcription factor (TF) overexpression to reprogram PSCs and various somatic cells. The induction of pluripotency with just four TFs by Yamanaka informs our ability to convert cell fates and demonstrates the feasibility of utilizing terminally differentiated cells to generate cells with multilineage potential. In this review, we discuss the recent efforts undertaken using TF-based reprogramming strategies to convert several cell types into HSCs.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.