ArticleCurrent biology : CB2016
period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- ENaC is a host susceptibility factor to bacterial infections in cystic fibrosis context.Communications biology · 2025Article
- Article
- Review
- Interactions between innate immunity and insulin signaling affect resistance to infection in insects.Frontiers in immunology · 2023Review
- TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila.Disease models & mechanisms · 2022Article
- Methodological tools to study species of the genus Burkholderia.Applied microbiology and biotechnology · 2021Review
- Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation.Cellular and molecular life sciences : CMLS · 2020Article
- Circadian regulation of mitochondrial uncoupling and lifespan.Nature communications · 2020Article
- Time after time: circadian clock regulation of intestinal stem cells.Cellular and molecular life sciences : CMLS · 2020Review
- Dissection of central clock function ineLife · 2019Article
- Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.Integrative and comparative biology · 2018Article
- A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa.PLoS genetics · 2018Article
- A mechanism for sickness sleep: lessons from invertebrates.The Journal of physiology · 2017Review
- Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila.Cell reports · 2017Article
- Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.Cell death and differentiation · 2017Article
- AThe Journal of cell biology · 2017Article
- Mated Drosophila melanogaster females consume more amino acids during the dark phase.PloS one · 2017Article
- Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per.Cell metabolism · 2016Article
- Thermoregulation as a disease tolerance defense strategy.Pathogens and disease · 2016Review
- GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock.Cell reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Most metazoans undergo dynamic, circadian-regulated changes in behavior and physiology. Currently, it is unknown how circadian-regulated behavior impacts immunity against infection. Two broad categories of defense against bacterial infection are resistance, control of microbial growth, and tolerance, control of the pathogenic effects of infection. Our study of behaviorally arrhythmic Drosophila circadian period mutants identified a novel link between nutrient intake and tolerance of infection with B. cepacia, a bacterial pathogen of rising importance in hospital-acquired infections. We found that infection tolerance in wild-type animals is stimulated by acute exposure to dietary glucose and amino acids. Glucose-stimulated tolerance was induced by feeding or direct injection; injections revealed a narrow window for glucose-stimulated tolerance. In contrast, amino acids stimulated tolerance only when ingested. We investigated the role of a known amino-acid-sensing pathway, the TOR (Target of Rapamycin) pathway, in immunity. TORC1 is circadian regulated and inhibition of TORC1 decreased resistance, as in vertebrates. Surprisingly, inhibition of the less well-characterized TOR complex 2 (TORC2) dramatically increased survival, through both resistance and tolerance mechanisms. This work suggests that dietary intake on the day of infection by B. cepacia can make a significant difference in long-term survival. We further demonstrate that TOR signaling mediates both resistance and tolerance of infection and identify TORC2 as a novel potential therapeutic target for increasing survival of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.