Evidence map›Paper›PMID 26748707›Full record

ArticleCell reports2016

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Bernat Baeza-Raja, Benjamin D Sachs, Pingping Li, Frank Christian, Eirini Vagena, Dimitrios Davalos, Natacha Le Moan, Jae Kyu Ryu, Shoana L Sikorski, Justin P Chan and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Journal of diabetes research · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Sexual Dimorphism in Balance and Coordination in p75NTRFrontiers in behavioral neuroscience · 2022
    Article
  15. In vivo functions of p75Trends in pharmacological sciences · 2021
    Review
  16. Metabolic homeostasis via BDNF and its receptors.Trends in endocrinology and metabolism: TEM · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Bernat Baeza-RajaGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Benjamin D SachsDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Pingping LiDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Frank ChristianInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Eirini VagenaGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Dimitrios DavalosGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Natacha Le MoanGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Jae Kyu RyuGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Shoana L SikorskiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Justin P ChanGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.
Miriam ScadengDepartment of Radiology, University of California, San Diego, La Jolla, CA 92093, USA.
Susan S TaylorDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Miles D HouslayInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
George S BaillieInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Alan R SaltielDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Jerrold M OlefskyDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Katerina AkassoglouGladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: kakassoglou@gladstone.ucsf.edu.
University of California, San Diego · USGladstone Institutes · USUniversity of California, San Francisco · USUniversity of Glasgow · GBKing's College London · GB

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Project# 4: INTERACTIONS OF ANCHORING PROTEINS WITH THEIR TARGETSP01DK054441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, SUSAN S. · 1999 to 2017
$27.3M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
The Interaction of Neuroendocrine Repro. Function and Metabolic SignalingU54HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1999 to 2013
$18.0M
Transcriptional Genomics CoreP01DK074868 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2007 to 2016
$16.6M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
The Role of G Proteins in Insulin ActionR01DK061618 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SALTIEL, ALAN R. · 2002 to 2016
$5.1M
Signaling Pathways in Insulin ActionR01DK060591 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SALTIEL, ALAN R. · 2002 to 2016
$4.9M
The Role of the Exocyst Complex in Insulin Regulated Glucose TransportR01DK076906 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SALTIEL, ALAN R. · 2007 to 2019
$4.6M
Mechanisms and functions of p75 neurotrophin receptor signaling in astrocytesR01NS051470 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKASSOGLOU, KATERINA · 2005 to 2015
$4.0M
Medical Research Council G0600765Medical Research Council J007412Medical Research Council MR/J007412/1NCI NIH HHS CA082103NICHD NIH HHS U54 HD012303NIDDK NIH HHS P01 DK054441NIDDK NIH HHS P01 DK074868NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK63720NIDDK NIH HHS R01 DK060591NIDDK NIH HHS R01 DK061618NIDDK NIH HHS R01 DK076906NIGMS NIH HHS T32 GM007752NINDS NIH HHS NS051470NINDS NIH HHS R01 NS051470
6 · The paper itself

Abstract

Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75(NTR)) controls energy expenditure in obese mice on a high-fat diet (HFD). Despite no changes in food intake, p75(NTR)-null mice were protected from HFD-induced obesity and remained lean as a result of increased energy expenditure without developing insulin resistance or liver steatosis. p75(NTR) directly interacts with the catalytic subunit of protein kinase A (PKA) and regulates cAMP signaling in adipocytes, leading to decreased lipolysis and thermogenesis. Adipocyte-specific depletion of p75(NTR) or transplantation of p75(NTR)-null white adipose tissue (WAT) into wild-type mice fed a HFD protected against weight gain and insulin resistance. Our results reveal that signaling from p75(NTR) to cAMP/PKA regulates energy balance and suggest that non-CNS neurotrophin receptor signaling could be a target for treating obesity and the metabolic syndrome.

Indexed as

AnimalsLipid MetabolismMiceMice, KnockoutObesityReceptor, Nerve Growth FactorSignal TransductionReceptor, Nerve Growth Factor

Identifiers

PMID26748707
PMCPMC4831919
OpenAlexW2219020170

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.