ArticleDrug and alcohol dependence2016
Insula reactivity to negative stimuli is associated with daily cigarette use: A preliminary investigation using the Human Connectome Database.
Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD).Drug and alcohol dependence · 2018Trial
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking.Addiction neuroscience · 2022Article
- The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation.Neuroscience and biobehavioral reviews · 2019Review
- Risk factors for nicotine dependence in Chinese patients with lung cancer.The Journal of international medical research · 2019Article
- Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundIndividuals who smoke more cigarettes per day are at greater risk for developing smoking-related illness and have more difficulty quitting. Withdrawal-related negative mood is one factor thought to motivate drug use. However, heavy smokers are generally more sensitive to negative affect, not just negative emotion stemming from withdrawal. One possibility is that individual differences in how the brain processes negative stimuli may impact smoking use. Given the wealth of data implicating the insula in nicotine dependence and affective processing we hypothesize that the number of cigarettes an individual smokes per day will relate to insula reactivity to negative stimuli.
methodsA functional magnetic resonance imaging (fMRI) emotional processing task collected by the Human Connectome Project was assessed in 21 daily tobacco smokers who reported smoking between 5 and 20 cigarettes per day. The number of cigarettes smoked per day was correlated with right and left anterior insula reactivity to faces expressing a negative emotion relative to a control. This anterior insula region of interest has been associated with treatment outcome and smoking cue-reactivity in our prior work.
resultsThose who smoked more daily cigarettes showed greater right insula reactivity to negative stimuli (r=0.564, p=0.008). Left insula reactivity was not associated with cigarettes smoked per day.
conclusionSmokers who use more cigarettes per day have greater insula reactivity to negative stimuli, furthering the field's understanding of the insula's involvement in nicotine use. This preliminary work also suggests a mechanism contributing to higher rates of daily smoking.
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