Trial reportJournal of Crohn's & colitis2016
The Impact of Magnetic Resonance Enterography and Capsule Endoscopy on the Re-classification of Disease in Patients with Known Crohn's Disease: A Prospective Israeli IBD Research Nucleus (IIRN) Study.
Trial report in Journal of Crohn's & colitis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic performance of magnetic resonance enterography and ultrasound in children with inflammatory bowel diseases: a diagnostic test accuracy meta-analysis.European radiology · 2022Pooled it
- Small bowel capsule endoscopy and treat-to-target in Crohn's disease: A systematic review.World journal of gastroenterology · 2019Pooled it
- A novel PillCam Crohn's capsule score (Eliakim score) for quantification of mucosal inflammation in Crohn's disease.United European gastroenterology journal · 2020Trial
- Imaging in inflammatory bowel disease 2025: ECCO-ESGAR-ESP-IBUS diagnostic and monitoring recommendations with MRI and intestinal ultrasound in treat-to-target strategies.Insights into imaging · 2026Review
- Capsule Endoscopy in Inflammatory Bowel Disease: Current Status and Issues in Clinical Practice.DEN open · 2026Review
- The Israeli IBD Research Nucleus: collaborative advancements in Israeli IBD research.Therapeutic advances in gastroenterology · 2026Review
- Accuracy of Imaging Scoring Indexes in Pediatric Crohn's Disease Patients.Biomedicines · 2025Article
- Review on Advances in Pediatric Endoscopy in the Management of Inflammatory Bowel Disease.Current pediatric reviews · 2025Review
- The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease.Diagnostics (Basel, Switzerland) · 2024Article
- Pan-Enteric Capsule Endoscopy: Current Applications and Future Perspectives.GE Portuguese journal of gastroenterology · 2024Review
- Video Capsule Endoscopy Plays an Important Role in the Management of Crohn's Disease.Diagnostics (Basel, Switzerland) · 2023Review
- Capsule Endoscopy Is Useful for Postoperative Tight Control Management in Patients with Crohn's Disease.Digestive diseases and sciences · 2022Article
- Diagnostic significance of mesenteric lymph node involvement in proximal small bowel Crohn's disease.Therapeutic advances in gastroenterology · 2022Article
- Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?Diagnostics (Basel, Switzerland) · 2021Review
- Assessment of a new score for capsule endoscopy in pediatric Crohn's disease (CE-CD).Endoscopy international open · 2021Article
- Panenteric capsule endoscopy identifies proximal small bowel disease guiding upstaging and treatment intensification in Crohn's disease: A European multicentre observational cohort study.United European gastroenterology journal · 2021Observational
- Body weight, serum albumin and food intolerance were linked to upper gastrointestinal Crohn's disease: a 7-year retrospective analysis.Annals of translational medicine · 2020Article
- Colon Capsule Endoscopy for Inflammatory Bowel Disease.Clinical endoscopy · 2020Review
- Economic analysis of the adoption of capsule endoscopy within the British NHS.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2020Article
- Objective evaluation for treat to target in Crohn's disease.Journal of gastroenterology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe classification of Crohn's disease (CD) is usually determined at initial diagnosis and is frequently based on ileocolonoscopic and cross-sectional imaging data. Advanced endoscopic and imaging techniques such as small-bowel video capsule endoscopy (VCE) and magnetic resonance enterography (MRE) may provide additional data regarding disease extent and phenotype. Our aim was to examine whether VCE or MRE performed after the initial diagnosis may alter the original disease classification.
methodsConsecutive patients with known small-bowel CD in clinical remission or mild disease were prospectively recruited and underwent MRE and VCE (if small-bowel patency was confirmed by a patency capsule (PC). Montreal classifications before and after evaluation were compared.
resultsSeventy-nine patients underwent MRE and VCE was performed in 56. Previously unrecognized disease locations were detected with VCE and MRE in 51 and 25%, respectively (p < 0.01) and by both modalities combined in 44 patients (55%). Twenty-two patients (27%) were reclassified as having an advanced phenotype (B2/B3). MRE and VCE reclassified the phenotype in 26 and 11% of cases, respectively (p < 0.05). Overall, both modalities combined altered the original Montreal classification in 49/76 patients (64%).
conclusionVCE and MRE may lead to reclassification of the original phenotype in a significant percentage of CD patients in remission. VCE was more sensitive for detection of previously unrecognized locations, while MRE was superior for detection of phenotype shift. The described changes in the disease classification may have an important impact on both clinical management and long-term prognosis in these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.