ArticleJournal of the mechanical behavior of biomedical materials2016
Stem cell therapy restores viscoelastic properties of myocardium in rat model of hypertension.
Article in Journal of the mechanical behavior of biomedical materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Distinct Right Ventricular Performance in Response to Acute Colchicine Treatment in Healthy and Diseased States.Function (Oxford, England) · 2025Article
- Alterations of biaxial viscoelastic properties of the right ventricle in pulmonary hypertension development in rest and acute stress conditions.Frontiers in bioengineering and biotechnology · 2023Article
- Strain-dependent stress relaxation behavior of healthy right ventricular free wall.Acta biomaterialia · 2022Article
- How viscous is the beating heart?: Insights from a computational study.Computational mechanics · 2022Article
- Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues.Matrix biology : journal of the International Society for Matrix Biology · 2022Review
- Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus.Scientific reports · 2018Article
- Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.Acta biomaterialia · 2018Article
- Hypertension-Linked Pathophysiological Alterations in the Gut.Circulation research · 2017Article
- Mechanical characterization of human brain tumors from patients and comparison to potential surgical phantoms.PloS one · 2017Article
- Hypertension-linked mechanical changes of rat gut.Acta biomaterialia · 2016Article
- An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats.International journal of cardiology · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Extensive remodeling of the myocardium is seen in a variety of cardiovascular diseases, including systemic hypertension. Stem cell therapy has been proposed to improve the clinical outcomes of hypertension, and we hypothesized that changes in mechanical properties of the myocardium would accompany the progression of disease and the results of treatment conditions. Using spontaneously hypertensive rats (SHR) as a model of hypertension, we treated 13-week-old hypertensive rats with a single injection of adipose-derived stem cells (ADSC) isolated from a normotensive control. We indented the isolated ventricles of control, untreated sham-injected SHR, and ADSC-treated SHR hearts with a custom cantilever-based system and fit the resulting data to a standard linear solid model. SHR animals had higher blood pressure (198.4±25.9mmHg) and lower ejection fraction (69.9±4.2%) than age-matched control animals (109.0±1.6mmHg, 88.2±1.3%), and increased viscoelastic properties accompanied these clinical changes (right ventricle effective stiffness, SHR: 21.97±5.10kPa, Control: 13.14±3.48kPa). ADSC-treated animals saw improvement in clinical parameters compared to the untreated SHR group, which was also accompanied by a significant restoration of viscoelastic properties of the myocardium (ACSD-treated SHR: 9.77±6.96kPa).
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