ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016
Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells.
Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Association between high serum ferritin and periodontitis: A population-based cross-sectional preliminary study.Journal of periodontology · 2026Article
- Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung.bioRxiv : the preprint server for biology · 2023Article
- Circulating inflammatory cytokines and hypertensive disorders of pregnancy: a two-sample Mendelian randomization study.Frontiers in immunology · 2023Article
- The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms.Frontiers in immunology · 2022Review
- Current View on the Mechanisms of Alcohol-Mediated Toxicity.International journal of molecular sciences · 2021Review
- The elevated expression of TLR4 and MMP9 in human abdominal aortic aneurysm tissues and its implication.BMC cardiovascular disorders · 2021Article
- Systemic Inflammatory Response and Outcomes in Community-Acquired Pneumonia Patients Categorized According to the Smoking Habit or Presence of Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2020Article
- The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders.Journal of cannabis research · 2020Article
- The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae.Alcohol (Fayetteville, N.Y.) · 2019Article
- Dose-dependent effects of chronic alcohol drinking on peripheral immune responses.Scientific reports · 2019Article
- Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort.European archives of psychiatry and clinical neuroscience · 2018Article
- The GABABrain sciences · 2018Article
- Peripheral TNFα elevations in abstinent alcoholics are associated with hepatitis C infection.PloS one · 2018Article
- Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Malondialdehyde-Acetaldehyde (MAA) Protein Adducts Are Found Exclusively in the Lungs of Smokers with Alcohol Use Disorders and Are Associated with Systemic Anti-MAA Antibodies.Alcoholism, clinical and experimental research · 2017Article
- TheFrontiers in aging neuroscience · 2017Article
- The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking.Alcoholism, clinical and experimental research · 2016Article
- Alcohol and lung injury and immunity.Alcohol (Fayetteville, N.Y.) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol use disorders (AUDs) and tobacco smoking are associated with an increased predisposition for community-acquired pneumonia and the acute respiratory distress syndrome. Mechanisms are incompletely established but may include alterations in response to pathogens by immune cells, including alveolar macrophages (AMs) and peripheral blood mononuclear cells (PBMCs). We sought to determine the relationship of AUDs and smoking to expression of IFNγ, IL-1β, IL-6, and TNFα by AMs and PBMCs from human subjects after stimulation with lipopolysaccharide (LPS) or lipoteichoic acid (LTA). AMs and PBMCs from healthy subjects with AUDs and controls, matched on smoking, were cultured with LPS (1 μg/ml) or LTA (5 μg/ml) in the presence and absence of the antioxidant precursor N-acetylcysteine (10 mM). Cytokines were measured in cell culture supernatants. Expression of IFNγ, IL-1β, IL-6, and TNFα in AMs and PBMCs was significantly increased in response to stimulation with LPS and LTA. AUDs were associated with augmented production of proinflammatory cytokines, particularly IFNγ and IL-1β, by AMs and PBMCs in response to LPS. Smoking diminished the impact of AUDs on AM cytokine expression. Expression of basal AM and PBMC Toll-like receptors-2 and -4 was not clearly related to differences in cytokine expression; however, addition of N-acetylcysteine with LPS or LTA led to diminished AM and PBMC cytokine secretion, especially among current smokers. Our findings suggest that AM and PBMC immune cell responses to LPS and LTA are influenced by AUDs and smoking through mechanisms that may include alterations in cellular oxidative stress.
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Registered trials
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