ReviewTrends in neurosciences2016
Call it Worm Sleep.
Review in Trends in neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 125 citations in OpenAlex.
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- A screen for stress-induced sleep genes in Caenorhabditis elegans reveals a role for glutamate signaling.Genetics · 2026Article
- A genetically encoded sensor of ionic stress links cellular proton dynamics to sleep.Science advances · 2026Article
- A circadian clock gene homolog regulates developmental timing and male mating circuitry iniScience · 2026Article
- GravSorter: a forward-genetics tool for studying gravity response inThe Analyst · 2026Article
- Article
- Caenorhabditis elegans models of alternating hemiplegia of childhood have dominant neuromuscular junction defects.Disease models & mechanisms · 2026Article
- Article
- Induction and regulation of reversible suspended animation in C. elegans.Nature communications · 2026Article
- Induction and regulation of a reversible form of suspended animation inbioRxiv : the preprint server for biology · 2026Article
- A genetically encoded ionic-stress sensor reveals protons as a sleep driver.bioRxiv : the preprint server for biology · 2026Article
- Harnessing Simple Animal Models to Decode Sleep Mysteries.Molecular biotechnology · 2025Review
- Pathogen infection induces sickness behaviors through neuromodulators linked to stress and satiety in C. elegans.Nature communications · 2025Article
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- New alleles ofmicroPublication biology · 2024Article
- Article
- Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The nematode Caenorhabditis elegans stops feeding and moving during a larval transition stage called lethargus and following exposure to cellular stressors. These behaviors have been termed 'sleep-like states'. We argue that these behaviors should instead be called sleep. Sleep during lethargus is similar to sleep regulated by circadian timers in insects and mammals, and sleep in response to cellular stress is similar to sleep induced by sickness in other animals. Sleep in mammals and Drosophila shows molecular and functional conservation with C. elegans sleep. The simple neuroanatomy and powerful genetic tools of C. elegans have yielded insights into sleep regulation and hold great promise for future research into sleep regulation and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.