ArticleAmerican journal of physiology. Heart and circulatory physiology2016
β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Cardiovascular β-Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue.Comprehensive Physiology · 2026Review
- Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- On the haemodynamic consequence of the chemoreflex and muscle mechanoreflex interaction in women and men: two tales, one story.The Journal of physiology · 2022Article
- Microvascular β-Adrenergic Receptor-Mediated Vasodilation Is Attenuated in Adults With Major Depressive Disorder.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2022Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/KMolecules (Basel, Switzerland) · 2019Article
- Sex differences in sympathetic vasoconstrictor responsiveness and sympatholysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Nitric oxide synthase and cyclooxygenase modulate β-adrenergic cutaneous vasodilatation and sweating in young men.The Journal of physiology · 2017Article
- Neurovascular control of blood pressure is influenced by aging, sex, and sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives.Frontiers in physiology · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypothesis that women exhibit greater vasodilator responses to β-adrenoceptor stimulation compared with men. We further hypothesized women exhibit a greater contribution of nitric oxide synthase and cyclooxygenase to β-adrenergic-mediated vasodilation compared with men. Forearm blood flow (Doppler ultrasound) was measured in young men (n = 29, 26 ± 1 yr) and women (n = 33, 25 ± 1 yr) during intra-arterial infusion of isoproterenol (β-adrenergic agonist). In subset of subjects, isoproterenol responses were examined before and after local inhibition of nitric oxide synthase [N(G)-monomethyl-l-arginine (l-NMMA); 6 male/10 female] and/or cyclooxygenase (ketorolac; 5 male/5 female). Vascular conductance (blood flow ÷ mean arterial pressure) was calculated to assess vasodilation. Vascular conductance increased with isoproterenol infusion (P < 0.01), and this effect was not different between men and women (P = 0.41). l-NMMA infusion had no effect on isoproterenol-mediated dilation in men (P > 0.99) or women (P = 0.21). In contrast, ketorolac infusion markedly increased isoproterenol-mediated responses in both men (P < 0.01) and women (P = 0.04) and this rise was lost with subsequent l-NMMA infusion (men, P < 0.01; women, P < 0.05). β-Adrenergic vasodilation is not different between men and women and sex differences in the independent contribution of nitric oxide synthase and cyclooxygenase to β-mediated vasodilation are not present. However, these data are the first to demonstrate β-adrenoceptor activation of cyclooxygenase suppresses nitric oxide synthase signaling in human forearm microcirculation and may have important implications for neurovascular control in both health and disease.
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