ArticleAmerican journal of physiology. Heart and circulatory physiology2016
Consequences of intravascular lymphatic valve properties: a study of contraction timing in a multi-lymphangion model.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mechanical feedback mechanisms in a multiscale sliding filament model of lymphatic muscle pumping.Applications in engineering science · 2025Article
- Control of lymphatic pacemaking and pumping by mechanobiological signals.The Journal of physiology · 2025Article
- Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull.Fluids and barriers of the CNS · 2024Article
- The Lymphatic Vascular System: Does Nonuniform Lymphangion Length Limit Flow-Rate?Journal of biomechanical engineering · 2024Article
- Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions.Biomechanics and modeling in mechanobiology · 2024Review
- A 1D model characterizing the role of spatiotemporal contraction distributions on lymph transport.Scientific reports · 2023Article
- Cerebrospinal fluid dynamics coupled to the global circulation in holistic setting: Mathematical models, numerical methods and applications.International journal for numerical methods in biomedical engineering · 2022Article
- Innovations in lymph node targeting nanocarriers.Seminars in immunology · 2021Review
- Fluid pumping of peristaltic vessel fitted with elastic valves.Journal of fluid mechanics · 2021Article
- Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation.Journal of the Royal Society, Interface · 2020Article
- Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep.Nature biomedical engineering · 2020Article
- The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.Scientific reports · 2019Article
- Contraction of collecting lymphatics: organization of pressure-dependent rate for multiple lymphangions.Biomechanics and modeling in mechanobiology · 2018Article
- Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography.Journal of biophotonics · 2018Article
- Differences in L-type CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Lymphatic System Flows.Annual review of fluid mechanics · 2018Article
- Valve-related modes of pump failure in collecting lymphatics: numerical and experimental investigation.Biomechanics and modeling in mechanobiology · 2017Article
- The relationship between lymphangion chain length and maximum pressure generation established through in vivo imaging and computational modeling.American journal of physiology. Heart and circulatory physiology · 2017Article
- Demonstration and Analysis of the Suction Effect for Pumping Lymph from Tissue Beds at Subatmospheric Pressure.Scientific reports · 2017Article
- Pump function curve shape for a model lymphatic vessel.Medical engineering & physics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The observed properties of valves in collecting lymphatic vessels include transmural pressure-dependent bias to the open state and hysteresis. The bias may reduce resistance to flow when the vessel is functioning as a conduit. However, lymphatic pumping implies a streamwise increase in mean pressure across each valve, suggesting that the bias is then potentially unhelpful. Lymph pumping by a model of several collecting lymphatic vessel segments (lymphangions) in series, which incorporated these properties, was investigated under conditions of adverse pressure difference while varying the refractory period between active muscular contractions and the inter-lymphangion contraction delay. It was found that many combinations of the timing parameters and the adverse pressure difference led to one or more intermediate valves remaining open instead of switching between open and closed states during repetitive contraction cycles. Cyclic valve switching was reliably indicated if the mean pressure in a lymphangion over a cycle was higher than that in the lymphangion upstream, but either lack of or very brief valve closure could cause mean pressure to be lower downstream. Widely separated combinations of refractory period and delay time were found to produce the greatest flow-rate for a given pressure difference. The efficiency of pumping was always maximized by a long refractory period and lymphangion contraction starting when the contraction of the lymphangion immediately upstream was peaking. By means of an ex vivo experiment, it was verified that intermediate valves in a chain of pumping lymphangions can remain open, while the lymphangions on either side of the open valve continue to execute contractions.
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