Evidence map›Paper›PMID 26747460›Full record

ArticleHead and neck pathology2016

Head and Neck Schwannomas: 20-Year Experience of a Single Institution Excluding Cutaneous and Acoustic Sites.

Randall T Butler, Rajiv M Patel, Jonathan B McHugh

Open access · bronzeAbstract read
In one paragraph

Article in Head and neck pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

  1. Transoral Robotic Approach for Pharyngeal Schwannoma.Diagnostics (Basel, Switzerland) · 2025
    Article
  2. Extracranial Head and Neck Schwannomas: A Single Centre Retrospective Experience of 97 Cases.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  3. Sinonasal Schwannoma: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  4. Article
  5. Article
  6. Laryngeal Schwannoma Triggered Life-threatening Acute Airway Obstruction- A Rare Case Report with Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  7. Review
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  9. Article
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  14. Article
  15. Palatal schwannoma in a young female patient: report of a case and review of the literature.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2018
    Review
  16. Article
  17. Article
  18. Sinonasal Schwannoma - A Case Report.Journal of clinical and diagnostic research : JCDR · 2017
    Article
  19. Article
  20. Schwannoma of the tongue.BMJ case reports · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Randall T ButlerDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Rajiv M PatelDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Jonathan B McHughDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA. jonamch@umich.edu.
University of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While head and neck sites comprise the most common location of schwannomas, clinicopathologic data regarding those tumors occurring in non-acoustic and non-cutaneous locations are relatively sparse. In this study, therefore, we sought to examine retrospectively the clinical and pathologic features of head and neck schwannomas excised at our institution over a 20-year period. During this period, we identified a total cohort of 85 patients, which included 36 males (42.4 %) and 49 females with average age of 41.3 years, the majority of which presented asymptomatically with a mass. Localized symptoms were, however, associated with all of the schwannomas that arose in the oral cavity and larynx, while tumors within or adjacent to bone were often associated with neurologic complaints (7 of 15 such tumors [46.7 %]). Clinical follow-up data was available in 86.4 % of all cases and demonstrated no recurrences or mortality. Pathologically, the microscopic features were characteristic of those well-described for schwannomas in other sites, including alternating Antoni A and B areas and the presence of degenerative changes. Tumor encapsulation, however, was variable and was completely absent in schwannomas of the nasal cavity, paranasal sinuses, and larynx. Additionally, a significant minority of the tumors (28.2 %) exhibited foci that resembled neurofibroma. Non-acoustic, non-cutaneous schwannomas of the head and neck appear to have clinicopathologic features similar to their soft tissue counterparts with some subsite variation in presentation and/or microscopic features.

Indexed as

AdultAgedFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedNeurilemmomaRetrospective StudiesYoung AdultNerve sheath tumorSchwannomaSinonasal

Identifiers

PMID26747460
PMCPMC4972753
OpenAlexW2224689940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.