SynthesisNeuroradiology2016
Testing flow diversion in animal models: a systematic review.
Synthesis in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A systematic review of the Woven EndoBridge device-do findings in pre-clinical animal models compare to clinical results?Acta neurochirurgica · 2023Pooled it
- Flow diversion: what can clinicians learn from animal models?Neuroradiology · 2017Pooled it
- Measuring artery diameter in rabbit angiograms for neurovascular disease modeling applications and device testing.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Rescue Stenting of Isolated Middle Cerebral Artery (MCA) Dissections (MCAD) with Antithrombogenic Coated Stents and Mono-Antiplatelet Therapy (MAPT).Journal of clinical medicine · 2024Article
- Evaluation of the EMBOPIPE flow diverter device: in vivo and in vitro experiments.Chinese neurosurgical journal · 2024Article
- Vascular Response on a Novel Fibrin-Based Coated Flow Diverter.Cardiovascular and interventional radiology · 2022Article
- Parent Artery Straightening after Flow-Diverter Stenting Improves the Odds of Aneurysm Occlusion.AJNR. American journal of neuroradiology · 2022Article
- Endogenous animal models of intracranial aneurysm development: a review.Neurosurgical review · 2021Review
- In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.Journal of neurointerventional surgery · 2021Article
- The development and understanding of intracranial aneurysm based on rabbit model.Neuroradiology · 2020Review
- Custom tissue engineered aneurysm models with varying neck size and height for early stage in vitro testing of flow diverters.Journal of materials science. Materials in medicine · 2020Article
- Prospective study to assess the tissue response to HPC-coated p48 flow diverter stents compared to uncoated devices in the rabbit carotid artery model.European radiology experimental · 2019Article
- Biodegradable Flow Diverter for the Treatment of Intracranial Aneurysms: A Pilot Study Using a Rabbit Aneurysm Model.Journal of the American Heart Association · 2019Article
- The pCONUS HPC: 30-Day and 180-Day In Vivo Biocompatibility Results.Cardiovascular and interventional radiology · 2019Article
- On Flow Diversion: The Changing Landscape of Intracerebral Aneurysm Management.AJNR. American journal of neuroradiology · 2019Review
- Re-treatment of residual aneurysms after flow diversion: An experimental study.The neuroradiology journal · 2018Article
- BioengineeredCardiovascular diagnosis and therapy · 2017Review
- Emerging Technologies in Flow Diverters and Stents for Cerebrovascular Diseases.Current neurology and neuroscience reports · 2017Review
- Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model.AJNR. American journal of neuroradiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFlow diversion (FD) is increasingly used to treat intracranial aneurysms. We sought to systematically review published studies to assess the quality of reporting and summarize the results of FD in various animal models.
methodsDatabases were searched to retrieve all animal studies on FD from 2000 to 2015. Extracted data included species and aneurysm models, aneurysm and neck dimensions, type of flow diverter, occlusion rates, and complications. Articles were evaluated using a checklist derived from the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines.
resultsForty-two articles reporting the results of FD in nine different aneurysm models were included. The rabbit elastase-induced aneurysm model was the most commonly used, with 3-month occlusion rates of 73.5%, (95%CI [61.9-82.6%]). FD of surgical sidewall aneurysms, constructed in rabbits or canines, resulted in high occlusion rates (100% [65.5-100%]). FD resulted in modest occlusion rates (15.4% [8.9-25.1%]) when tested in six complex canine aneurysm models designed to reproduce more difficult clinical contexts (large necks, bifurcation, or fusiform aneurysms). Adverse events, including branch occlusion, were rarely reported. There were no hemorrhagic complications. Articles complied with 20.8 ± 3.9 of 41 ARRIVE items; only a small number used randomization (3/42 articles [7.1%]) or a control group (13/42 articles [30.9%]).
conclusionPreclinical studies on FD have shown various results. Occlusion of elastase-induced aneurysms was common after FD. The model is not challenging but standardized in many laboratories. Failures of FD can be reproduced in less standardized but more challenging surgical canine constructions. The quality of reporting could be improved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.