Evidence map›Paper›PMID 26746866›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.

He Wu, Tao Wu, Xiaoning Han, Jieru Wan, Chao Jiang, Wenwu Chen, Hong Lu, Qingwu Yang, Jian Wang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase pathway.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

He WuDepartment of Pathology, First Clinical Hospital, Harbin Medical University, Harbin, China wuher2009@hotmail.com.
Tao WuStroke Center, Stroke Screening and Intervention Base, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xiaoning HanDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Jieru WanDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Chao JiangDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Wenwu ChenDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Hong LuDepartment of Neurology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Qingwu YangDepartment of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Jian WangDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA jwang79@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USArmy Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

Neuroprotective effect of flavanol (-) epicatechin after intracerebral hemorrhageR01AT007317 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$2.0M
PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhageR01NS078026 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$1.8M
Role of PGE2 receptors in the aging brain after intracerebral hemorrhageK01AG031926 · NIA · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2008 to 2012
$536k
NCCIH NIH HHS R01 AT007317NIA NIH HHS K01 AG031926NINDS NIH HHS R01 NS078026
6 · The paper itself

Abstract

Inflammatory responses mediated by prostaglandins such as PGE

Indexed as

AgingAnimalsBrain InjuriesCerebral HemorrhageCollagenasesInflammationMaleMiceNeuronsNeuroprotective AgentsOxidative StressReceptors, Prostaglandin E, EP2 SubtypeCollagenasesNeuroprotective AgentsReceptors, Prostaglandin E, EP2 SubtypeHigh-mobility group box 1inflammationPGE2prostaglandin receptor

Identifiers

PMID26746866
PMCPMC5363749
OpenAlexW2227816066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.