Evidence map›Paper›PMID 26746597›Full record

ArticleOphthalmology2016

Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes.

Na'ama Hammel, Akram Belghith, Christopher Bowd, Felipe A Medeiros, Lucie Sharpsten, Nadia Mendoza, Andrew J Tatham, Naira Khachatryan, Jeffrey M Liebmann, Christopher A Girkin and 2 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00221897 recruitingnot on this map

Diagnostic Innovations in Glaucoma Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2030Enrolled3,000ConditionsPrimary Open Angle Glaucoma, Myopia
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Na'ama HammelHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Akram BelghithHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Christopher BowdHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Felipe A MedeirosHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Lucie SharpstenHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Nadia MendozaHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Andrew J TathamHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Naira KhachatryanHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Jeffrey M LiebmannHarkness Eye Institute, Columbia University Medical Center, New York, New York.
Christopher A GirkinSchool of Medicine, University of Alabama, Birmingham, Alabama.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, and Department of Ophthalmology, University of California, San Diego, La Jolla, California. Electronic address: lzangwill@ucsd.edu.

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
Predicting and Detecting Glaucomatous Progression Using Pattern RecognitionR01EY022039 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOWD, CHRISTOPHER · 2012 to 2015
$1.5M
NEI NIH HHS EY019869NEI NIH HHS EY021818NEI NIH HHS EY022039NEI NIH HHS EY11008NEI NIH HHS P30 EY022589NEI NIH HHS P30EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY021818NEI NIH HHS R01 EY022039NEI NIH HHS U10 EY014267NEI NIH HHS U10EY14267
6 · The paper itself

Abstract

purposeTo characterize the rate and pattern of age-related and glaucomatous neuroretinal rim area changes in subjects of African and European descent.

designProspective longitudinal study.

participantsTwo hundred ninety-six eyes of 157 healthy subjects (88 patients of African descent and 69 of European descent) and 73 progressing glaucoma eyes of 67 subjects (24 patients of African descent and 43 of European descent) from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study were included.

methodsGlobal and sectoral rim areas were measured using confocal laser scanning ophthalmoscopy. Masked stereophotograph review determined progression of glaucomatous optic disc damage. The rates of absolute rim area loss and percentage rim area loss in healthy and progressing glaucomatous eyes were compared using multivariate, nested, mixed-effects models.

main outcome measuresRate of rim area loss over time.

resultsThe median follow-up time was 5.0 years (interquartile range, 2.0-7.4 years) for healthy eyes and 8.3 years (interquartile range, 7.5-9.9 years) for progressing glaucoma eyes. The mean rate of global rim area loss was significantly faster in progressing glaucomatous eyes compared with healthy eyes for both rim area loss (-10.2×10(-3) vs. -2.8×10(-3) mm(2)/year, respectively; P < 0.001) and percentage rim area loss (-1.1% vs. -0.2%/year, respectively; P < 0.001), but considerable overlap existed between the 2 groups. Sixty-three percent of progressing glaucoma eyes had a rate of change faster than the fifth quantile of healthy eyes. For both healthy and progressing eyes, the pattern of rim area loss and percentage rim area loss were similar, tending to be fastest in the superior temporal and inferior temporal sectors. The rate of change was similar in progressing eyes of patients of African or European descent.

conclusionsCompared with healthy eyes, the mean rate of global rim area loss was 3.7 times faster and the mean rate of global percentage rim area loss was 5.4 times faster in progressing glaucoma eyes. A reference database of healthy eyes can be used to help clinicians distinguish age-related rim area loss from rim area loss resulting from glaucoma.

Indexed as

AdultAgedAged, 80 and overBlack PeopleDisease ProgressionFemaleFollow-Up StudiesGlaucoma, Open-AngleHealthy VolunteersHumansIntraocular PressureMaleMiddle AgedOphthalmoscopyOptic DiskOptic Nerve Diseases

Identifiers

PMID26746597
PMCPMC4808425

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Registered trials

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