Evidence map›Paper›PMID 26746331›Full record

ArticleWorld neurosurgery2016

A Modern Radiotherapy Series of Survival in Hispanic Patients with Glioblastoma.

Cheng-Chia Wu, Tony J C Wang, Ashish Jani, Juan P Estrada, Timothy Ung, Daniel S Chow, Jennifer E Soun, Shumaila Saad, Yasir H Qureshi, Robyn Gartrell and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Cheng-Chia WuDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Tony J C WangDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA. Electronic address: tjw2117@cumc.columbia.edu.
Ashish JaniDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Juan P EstradaDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Timothy UngDepartment of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Daniel S ChowDepartment of Radiology, Columbia University Medical Center, New York, New York, USA.
Jennifer E SounDepartment of Radiology, Columbia University Medical Center, New York, New York, USA.
Shumaila SaadDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Yasir H QureshiTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.
Robyn GartrellDivision of Pediatric Hematology/Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, New York, USA.
Heva J SaadatmandDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Anurag SarafDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Matthew D GarrettDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Christopher S GrubbDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA.
Steven R IsaacsonDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA; Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Simon K ChengDepartment of Radiation Oncology, Columbia University Medical Center, New York, New York, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.
Michael B SistiHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA; Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Jeffrey N BruceHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA; Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Sameer A ShethDepartment of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Andrew B LassmanHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Guy M McKhannHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA; Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.

Funding

The Brief Research in Aging and Interdisciplinary NeurosciencesT35AG044303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sachin Agarwal, Jennifer Jaie Manly · 2013 to 2026
$1.9M
NIA NIH HHS T35 AG044303
6 · The paper itself

Abstract

backgroundStudies have shown racial differences in cancer outcomes. We investigate whether survival differences existed in Hispanic patients with glioblastoma (GBM) compared with other ethnicities from our modern radiotherapy series, because no study to date has focused on outcomes in this group after radiation therapy.

methodsWe retrospectively evaluated 428 patients diagnosed with GBM from 1996 to 2014 at our institution, divided into 4 groups based on self-report: white, black, Hispanic, and Asian/Indian. The primary outcome was overall survival. We analyzed differences in prognostic factors among the whole cohort compared with the Hispanic cohort alone.

resultsBaseline characteristics of the 4 racial groups were comparable. With a median follow-up of 387 days, no survival differences were seen by Kaplan-Meier analysis. Median overall survival for Hispanic patients was 355 days versus 450 days for the entire cohort. Factors significant for patient outcomes in the entire cohort differed slightly from those specific to Hispanic patients. Low Karnofsky Performance Status was significant on multivariate analysis in the whole population, but not in Hispanic patients. Extent of resection, recursive partitioning analysis class, and radiation therapy total dose were significant on multivariate analysis in both the whole population and Hispanic patients.

conclusionsWe found that Hispanic patients with GBM had no difference in survival compared with other ethnicities in our cohort. Differences exist in factors associated with outcomes on single and multivariate analysis for Hispanic patients with GBM compared with the entire cohort. Additional studies focusing on Hispanic patients will aid in more personalized treatment approaches in this group.

Indexed as

AdultAgedAged, 80 and overAge DistributionBrain NeoplasmsCranial IrradiationFemaleGlioblastomaHispanic or LatinoHumansMaleMiddle AgedNew YorkPrevalenceRadiotherapy DosageRisk FactorsEthnicityGlioblastomaHispanicRaceRadiation Therapy

Identifiers

PMID26746331
PMCPMC7255496

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.