ArticleSocial cognitive and affective neuroscience2016
Pain empathy in schizophrenia: an fMRI study.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Overlapping and specific neural correlates for empathizing, affective mentalizing, and cognitive mentalizing: A coordinate-based meta-analytic study.Human brain mapping · 2021Pooled it
- Intrinsic connectivity patterns of striatal subfields predict individual dimensions of psychopathology and are associated with cholinergic and serotonergic neurotransmission in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task.Schizophrenia bulletin · 2025Article
- Exploring Pain Empathy Among Doctors, Nurses and Patients: A Scoping Review.Journal of multidisciplinary healthcare · 2025Review
- No Sex-based Differences in Self-reported Empathy between Patients with Schizophrenia and Control Subjects.Actas espanolas de psiquiatria · 2024Article
- Emotional Contagion and Emotional Mimicry in Individuals with Schizophrenia: A Systematic Review.Journal of clinical medicine · 2024Review
- Empathy in schizophrenia: neural alterations during emotion recognition and affective sharing.Frontiers in psychiatry · 2024Article
- Validation of behavioral measures of social cognition in individuals diagnosed with schizophrenia.Frontiers in psychology · 2024Article
- Empathic disequilibrium as a new framework for understanding individual differences in psychopathology.Frontiers in psychology · 2023Article
- Involvement of the intrinsic functional network of the red nucleus in complex behavioral processing.Cerebral cortex communications · 2022Article
- Social Cognition and Schizophrenia: Unresolved Issues and New Challenges in a Maturing Field of Research.Schizophrenia bulletin · 2020Article
- Nonsocial and social cognition in schizophrenia: current evidence and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- Social affective context reveals altered network dynamics in schizophrenia patients.Translational psychiatry · 2018Article
- Neural Mechanisms With Respect to Different Paradigms and Relevant Regulatory Factors in Empathy for Pain.Frontiers in neuroscience · 2018Review
- Functional MRI examination of empathy for pain in people with schizophrenia reveals abnormal activation related to cognitive perspective-taking but typical activation linked to affective sharing.Journal of psychiatry & neuroscience : JPN · 2017Article
- Neuronal activation patterns during self-referential pain imagination.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although it has been proposed that schizophrenia is characterized by impaired empathy, several recent studies found intact neural responses on tasks measuring the affective subdomain of empathy. This study further examined affective empathy in 21 schizophrenia outpatients and 21 healthy controls using a validated pain empathy paradigm with two components: (i) observing videos of people described as medical patients who were receiving a painful sound stimulation treatment; (ii) listening to the painful sounds (to create regions of interest). The observing videos component incorporated experimental manipulations of perspective taking (instructions to imagine 'Self' vs 'Other' experiencing pain) and cognitive appraisal (information about whether treatment was 'Effective' vs 'Not Effective'). When considering activation across experimental conditions, both groups showed similar dorsal anterior cingulate cortex (dACC) and anterior insula (AI) activation while merely observing others in pain. However, there were group differences associated with perspective taking: controls showed relatively greater dACC and AI activation for the Self vs Other contrast whereas patients showed relatively greater activation in these and additional regions for the Other vs Self contrast. Although patients demonstrated grossly intact neural activity while observing others in pain, they showed more subtle abnormalities when required to toggle between imagining themselves vs others experiencing pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.