ArticleReproductive toxicology (Elmsford, N.Y.)2016
The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.
Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
54 citing papers in PubMed, 122 citations in OpenAlex.
- Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.The Journal of reproduction and development · 2026Review
- Integrated transcriptome analysis of rats exposed to bisphenol mixtures from the fetal to developmental stage.Toxicology research · 2025Article
- Developmental programming: mechanisms of early exposure to real-life chemicals in biosolids on offspring ovarian dynamics†.Biology of reproduction · 2025Article
- Uterine Microbiota and Bisphenols: Novel Influencers in Reproductive Health.Journal of xenobiotics · 2025Review
- Impact of Bisphenol A and its alternatives on oocyte health: a scoping review.Human reproduction update · 2024Article
- Environmental factors affecting female fertility.Endocrine · 2024Review
- Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress.Journal of ovarian research · 2024Article
- Review
- An Overview of the Health Effects of Bisphenol A from a One Health Perspective.Animals : an open access journal from MDPI · 2023Review
- High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis.Toxicology in vitro : an international journal published in association with BIBRA · 2023Article
- Different types of bisphenols alter ovarian steroidogenesis: Special attention to BPA.Heliyon · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Bisphenol-S Influence on Oxidative Stress and Endocrine Biomarkers of Reproductive System: A Systematic Review and Meta-Analysis.International journal of preventive medicine · 2023Review
- Microplastics exposure: implications for human fertility, pregnancy and child health.Frontiers in endocrinology · 2023Review
- Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.Cells · 2022Review
- Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway.Metabolic brain disease · 2022Article
- Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat.Environmental health perspectives · 2021Article
- [Effects of bisphenol A on apoptosis of ovarian preantral follicular granulosa cells and ovarian development in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality.Advances in experimental medicine and biology · 2021Article
- Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bisphenol A is used in polycarbonate plastics and epoxy resins. Previous studies show that in utero BPA exposure inhibits germ cell nest breakdown in the F1 generation of mice, but its effects on germ cell nest breakdown and on the ovary in the F2-F3 generations were unknown. Thus, we tested the hypothesis that BPA has transgenerational effects on the ovary. Mice were exposed to BPA in utero (BPA 0.5, 20, or 50μg/kg/day), and ovaries were collected at postnatal days (PND) 4 and 21 from the F1-F3 generations and subjected to histological evaluation and gene expression analyses. In utero BPA exposure did not have transgenerational effects on germ cell nest breakdown and gene expression on PND 4, but it caused transgenerational changes in expression in multiple genes on PND 21. Collectively, these data indicate that in utero BPA exposure has some transgenerational effects in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.