Evidence map›Paper›PMID 26745987›Full record

ArticleMolecular brain2016

Effect of context exposure after fear learning on memory generalization in mice.

Ayano Fujinaka, Ruoshi Li, Masanobu Hayashi, Deependra Kumar, Gopakumar Changarathil, Keisuke Naito, Kousuke Miki, Taihei Nishiyama, Michael Lazarus, Takeshi Sakurai and 4 more

Abstract read
In one paragraph

Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Measuring human context fear conditioning and retention after consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2023
    Article
  6. Article
  7. What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ayano FujinakaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. s1111651@u.tsukuba.ac.jp.
Ruoshi LiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. s1411707@u.tsukuba.ac.jp.
Masanobu HayashiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. genome1214@gmail.com.
Deependra KumarInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. drkdeependra@gmail.com.
Gopakumar ChangarathilInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. gopkmr.c@gmail.com.
Keisuke NaitoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. keisukenaito6@gmail.com.
Kousuke MikiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. tres.arboles419@gmail.com.
Taihei NishiyamaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. taihei.nishiyama.5320710@gmail.com.
Michael LazarusInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. lazarus.michael.ka@u.tsukuba.ac.jp.
Takeshi SakuraiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. Takeshi.Sakurai@gmail.com.
Nohjin KeeUniversity of Toronto, Toronto, Canada. nohjin.kee@alumni.utoronto.ca.
Satomi NakajimaDepartment of Adult Mental Health, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo, Japan. nakajima@ncnp.go.jp.
Szu-Han WangCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. szuhan.wang@gmail.com.
Masanori SakaguchiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. masanori.sakaguchi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.

resultsUsing a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.

conclusionsOur results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.

Indexed as

AnimalsFearGeneralization, ResponseMemoryMice, Inbred C57BL

Identifiers

PMID26745987
PMCPMC4706703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.