ArticleEnvironmental research2016
Mercury exposure and a shift toward oxidative stress in avid seafood consumers.
Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Multi-Element Exposure in a High-Altitude Páramo Mining District and Oxidative Stress Biomarkers in Gold Miners.Toxics · 2026Article
- Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys.International journal of hygiene and environmental health · 2021Article
- The Prevalence of Inorganic Mercury in Human Kidneys Suggests a Role for Toxic Metals in Essential Hypertension.Toxics · 2021Article
- Mercury in Pancreatic Cells of People with and without Pancreatic Cancer.International journal of environmental research and public health · 2020Article
- Selenium modifies associations between multiple metals and neurologic symptoms in Gulf states residents.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Vascular Dysfunction Induced by Mercury Exposure.International journal of molecular sciences · 2019Review
- Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans.Oxidative medicine and cellular longevity · 2019Review
- Low levels of lead and glutathione markers of redox status in human blood.Environmental geochemistry and health · 2018Article
- Full Atrioventricular Block Secondary to Acute Poisoning Mercury: A Case Report.International journal of environmental research and public health · 2018Article
- Modulators of mercury risk to wildlife and humans in the context of rapid global change.Ambio · 2018Article
- Article
- Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway.International journal of molecular medicine · 2018Article
- Glutamate‑mediated effects of caffeine and interferon‑γ on mercury-induced toxicity.International journal of molecular medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms of mercury (Hg) toxicity at low doses from seafood consumption, the most common exposure route, are not well understood. We tested the hypothesis that seafood Hg exposure is related to a shift in redox status, indicated by a decrease in the ratio of reduced to oxidized glutathione (GSH:GSSG) in blood, or increase in redox potential (Eh). We also examined whether key seafood nutrients (selenium (Se), omega-3 fatty acids) confound or modify this shift. We measured blood concentrations of total Hg, Se, GSH, GSSG, and the Omega-3 Index (% omega-3s of total fatty acids in red blood cell membranes) in seafood consumers in Long Island, NY. We examined relationships between Hg, GSH:GSSG ratio and Eh. Elevated blood Hg (>5.8µgL(-1)) was associated with lower GSH:GSSG (β=-116.73, p=0.01), with no evidence of confounding by Se or Omega-3 Index. However, in models stratified by Omega-3 Index levels, Hg-GSH:GSSG associations were weakened among those with high Omega-3 Index levels (>6% of fatty acids, β=-63.46, p=0.28), and heightened among those with low Omega-3 Index (β=-182.53, p<0.01). We observed comparable patterns for Eh in relation to Hg. These results support the hypothesis that Hg exposure from seafood is linked to a shift in redox status toward oxidative stress, modified by omega-3 fatty acids in this population. Further work should examine the role of different seafood nutrients and Hg-induced shifts in redox status in the diverse health effects associated with elevated Hg exposure.
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Registered trials
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