Evidence map›Paper›PMID 26745669›Full record

ArticleMolecular endocrinology (Baltimore, Md.)2016

Research Resource: Hormones, Genes, and Athleticism: Effect of Androgens on the Avian Muscular Transcriptome.

Matthew J Fuxjager, Jae-Hyung Lee, Tak-Ming Chan, Jae Hoon Bahn, Jenifer G Chew, Xinshu Xiao, Barney A Schlinger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Layered evolution of gene expression in "superfast" muscles for courtship.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Review
  6. Preparing to migrate: expression of androgen signaling molecules and insulin-like growth factor-1 in skeletal muscles of Gambel's white-crowned sparrows.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019
    Article
  7. Article
  8. Evolution of the androgen-induced male phenotype.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018
    Review
  9. The evolution of androgen receptor expression and behavior in Anolis lizard forelimb muscles.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018
    Article
  10. Insight into the neuroendocrine basis of signal evolution: a case study in foot-flagging frogs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018
    Review
  11. Increased androgenic sensitivity in the hind limb muscular system marks the evolution of a derived gestural display.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Matthew J FuxjagerDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Jae-Hyung LeeDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Tak-Ming ChanDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Jae Hoon BahnDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Jenifer G ChewDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Xinshu XiaoDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Barney A SchlingerDepartment of Biology (M.J.F.), Wake Forest University, Winston-Salem, North Carolina 27109; Department of Life and Nanopharmaceutical Sciences (J.-H.L.), and Department of Maxillofacial Biomedical Engineering (J.-H.L.), School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea; Department of Integrative Biology and Physiology (M.J.F., J.-H.L., T.-M.C., J.H.B., J.G.C., X.X., B.A.S.) and Laboratory of Neuroendocrinology (M.J.F., B.A.S.), Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; and Smithsonian Tropical Research Institute (B.A.S.), 0843-03092 Balboa, Ancón, Panama.
Wake Forest University · USKyung Hee University · KR

Funding

Neuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9M
Functional genetic variations in splicing regulationR01HG006264 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI XIAO, XINSHU GRACE · 2012 to 2016
$1.5M
NHGRI NIH HHS R01 HG006264NHGRI NIH HHS R01HG006264NICHD NIH HHS T32 HD007228
6 · The paper itself

Abstract

Male vertebrate social displays vary from physically simple to complex, with the latter involving exquisite motor command of the body and appendages. Studies of these displays have, in turn, provided substantial insight into neuromotor mechanisms. The neotropical golden-collared manakin (Manacus vitellinus) has been used previously as a model to investigate intricate motor skills because adult males of this species perform an acrobatic and androgen-dependent courtship display. To support this behavior, these birds express elevated levels of androgen receptors (AR) in their skeletal muscles. Here we use RNA sequencing to explore how testosterone (T) modulates the muscular transcriptome to support male manakin courtship displays. In addition, we explore how androgens influence gene expression in the muscles of the zebra finch (Taenopygia guttata), a model passerine bird with a limited courtship display and minimal muscle AR. We identify androgen-dependent, muscle-specific gene regulation in both species. In addition, we identify manakin-specific effects that are linked to muscle use during the manakin display, including androgenic regulation of genes associated with muscle fiber contractility, cellular homeostasis, and energetic efficiency. Overall, our results point to numerous genes and gene networks impacted by androgens in male birds, including some that underlie optimal muscle function necessary for performing acrobatic display routines. Manakins are excellent models to explore gene regulation promoting athletic ability.

Indexed as

AthletesBiomedical ResearchAndrogensAnimalsBirdsCourtshipGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksHumansMaleMolecular Sequence AnnotationMuscle, SkeletalPrincipal Component AnalysisReceptors, AndrogenAndrogensReceptors, AndrogenRNA, Messenger

Identifiers

PMID26745669
PMCPMC4792231
OpenAlexW2222653528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.