ArticleAmerican journal of respiratory and critical care medicine2016
Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 79 citations in OpenAlex.
- Left atrial pressure continuous monitoring improves early postoperative outcomes after double-lung transplantation for pulmonary hypertension.JTCVS open · 2026Article
- Impact of preoperative left ventricular diastolic dysfunction on primary graft dysfunction and mortality following lung transplantation.Journal of thoracic disease · 2025Article
- Extended Use of Central Veno-Arterial Extracorporeal Membrane Oxygenation in Lung Transplantation for Patients with Pulmonary Arterial Hypertension.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Transesophageal echocardiography during lung transplantation (Review).Experimental and therapeutic medicine · 2025Review
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients.Clinics and practice · 2024Article
- Do not forget about the left ventricle after lung transplantation for pulmonary hypertension.JHLT open · 2024Article
- Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Predictors of early mortality after lung transplantation for idiopathic pulmonary arterial hypertension.Pulmonary circulation · 2024Article
- Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation.Frontiers in immunology · 2024Review
- Complications related to extracorporeal life support in lung transplantation: single-center analysis.Journal of thoracic disease · 2023Article
- Pulmonary, circulatory and renal considerations in the early postoperative management of the lung transplant recipient.Global cardiology science & practice · 2023Review
- Primary graft dysfunction grade 3 following pediatric lung transplantation is associated with chronic lung allograft dysfunction.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers.World journal of transplantation · 2023Review
- Pulmonary Hypertension Association's 2022 International Conference Scientific Sessions Overview.Pulmonary circulation · 2023Article
- Intraoperative Circulatory Support in Lung Transplantation: Current Trend and Its Evidence.Life (Basel, Switzerland) · 2022Review
- New strategy to resume and taper epoprostenol after lung transplant for pulmonary hypertension.General thoracic and cardiovascular surgery · 2022Article
- Anesthetic considerations in lung transplantation: past, present and future.Journal of thoracic disease · 2021Review
- Primary graft dysfunction: what we know.Journal of thoracic disease · 2021Review
- Extracorporeal membrane oxygenation in lung transplantation: Indications, techniques and results.World journal of transplantation · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
rationalePrimary graft dysfunction (PGD) is a significant cause of early morbidity and mortality after lung transplant and is characterized by severe hypoxemia and infiltrates in the allograft. The pathogenesis of PGD involves ischemia-reperfusion injury. However, subclinical increases in pulmonary venous pressure due to left ventricular diastolic dysfunction may contribute by exacerbating capillary leak.
objectivesTo determine whether a higher ratio of early mitral inflow velocity (E) to early diastolic mitral annular velocity (é), indicative of worse left ventricular diastolic function, is associated with a higher risk of PGD.
methodsWe performed a retrospective cohort study of patients in the Lung Transplant Outcomes Group who underwent bilateral lung transplant at our institution between 2004 and 2014 for interstitial lung disease, chronic obstructive pulmonary disease, or pulmonary arterial hypertension. Transthoracic echocardiograms obtained during evaluation for transplant listing were analyzed for E/é and other measures of diastolic function. PGD was defined as PaO2/FiO2 less than or equal to 200 with allograft infiltrates at 48 or 72 hours after reperfusion. The association between E/é and PGD was assessed with multivariable logistic regression. MEASUREMENTS AND MAIN
resultsAfter adjustment for recipient age, body mass index, mean pulmonary arterial pressure, and pretransplant diagnosis, higher E/é and E/é greater than 8 were associated with an increased risk of PGD (E/é odds ratio, 1.93; 95% confidence interval, 1.02-3.64; P = 0.04; E/é >8 odds ratio, 5.29; 95% confidence interval, 1.40-20.01; P = 0.01).
conclusionsDifferences in left ventricular diastolic function may contribute to the development of PGD. Future trials are needed to determine whether optimization of left ventricular diastolic function reduces the risk of PGD.
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