ArticleBiophysical journal2016
Quantitative Morphology of Epithelial Folds.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Shaping epithelial tissues by stem cell mechanics in development and cancer.Nature reviews. Molecular cell biology · 2025Review
- Reverse engineering morphogenesis through Bayesian optimization of physics-based models.NPJ systems biology and applications · 2024Article
- The mechanical influence of densification on epithelial architecture.PLoS computational biology · 2024Article
- Size-dependent response of cells in epithelial tissue modulated by contractile stress fibers.Biophysical journal · 2023Article
- Collective behavior and self-organization in neural rosette morphogenesis.Frontiers in cell and developmental biology · 2023Review
- Organoid Cultures In Silico: Tools or Toys?Bioengineering (Basel, Switzerland) · 2022Review
- Pinching and pushing: fold formation in the Drosophila dorsal epidermis.Biophysical journal · 2021Article
- Morphologies of compressed active epithelial monolayers.The European physical journal. E, Soft matter · 2021Article
- Buckling of an Epithelium Growing under Spherical Confinement.Developmental cell · 2020Article
- Article
- Imaging the Cell Morphological Response to 3D Topography and Curvature in Engineered Intestinal Tissues.Frontiers in bioengineering and biotechnology · 2020Article
- Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.Developmental cell · 2019Article
- Nonlinear and nonlocal elasticity in coarse-grained differential-tension models of epithelia.Physical review. E · 2019Article
- Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset.Nature communications · 2018Article
- Scutoids are a geometrical solution to three-dimensional packing of epithelia.Nature communications · 2018Article
- Folding artificial mucosa with cell-laden hydrogels guided by mechanics models.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Epithelial Folding Driven by Apical or Basal-Lateral Modulation: Geometric Features, Mechanical Inference, and Boundary Effects.Biophysical journal · 2017Article
- Vertex models: from cell mechanics to tissue morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The shape of spatially modulated epithelial morphologies such as villi and crypts is usually associated with the epithelium-stroma area mismatch leading to buckling. We propose an alternative mechanical model based on intraepithelial stresses generated by differential tensions of apical, lateral, and basal sides of cells as well as on the elasticity of the basement membrane. We use it to theoretically study longitudinal folds in simple epithelia and we identify four types of corrugated morphologies: compact, invaginated, evaginated, and wavy. The obtained tissue contours and thickness profiles are compared to epithelial folds observed in invertebrates and vertebrates, and for most samples, the agreement is within the estimated experimental error. Our model establishes the groove-crest modulation of tissue thickness as a morphometric parameter that can, together with the curvature profile, be used to estimate the relative differential apicobasal tension in the epithelium.
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