ArticleBiophysical journal2016
Diffusion of Bacterial Cells in Porous Media.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Cell-body curvature reduces stall frequency to enhance Vibrio cholerae swimming and chemotaxis through hydrogels.Communications biology · 2026Article
- Dual chemotaxis strategy of bacteria in porous media: Run-time and turn-angle bias.Biophysical journal · 2026Article
- Multimodal holotomography for volumetric monitoring of host-pathogen interactions.Biomedical engineering online · 2026Article
- Article
- In Situ Quantification of Bacterial Surface Charge at the Single-Cell Level for Modeling Transport under Electric Fields.Environmental science & technology · 2026Article
- Characterizing Spatiotemporal Expansion of Pseudomonas aeruginosa Communities in Polymer and Mucin Gel Environments.Biotechnology and bioengineering · 2026Article
- Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulateProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cell-body curvature modulates stall frequency to enhancebioRxiv : the preprint server for biology · 2026Article
- Bacterial swimming in porous gels exhibits intermittent run motility with active turns and mechanical trapping.Scientific reports · 2025Article
- Coarse-graining bacterial diffusion in disordered media to surface states.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nongenetic adaptation by collective migration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Navigated range expansion promotes migratory culling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microbes in porous environments: from active interactions to emergent feedback.Biophysical reviews · 2024Review
- Motility mediates satellite formation in confined biofilms.The ISME journal · 2023Article
- Article
- Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A geometric criterion for the optimal spreading of active polymers in porous media.Nature communications · 2021Article
- Escherichia coli chemotaxis is information limited.Nature physics · 2021Article
- Chemotactic migration of bacteria in porous media.Biophysical journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The chemotaxis signal transduction network regulates the biased random walk of many bacteria in favorable directions and away from harmful ones through modulating the frequency of directional reorientations. In mutants of diverse bacteria lacking the chemotaxis response, migration in classic motility agar, which constitutes a fluid-filled porous medium, is compromised; straight-swimming cells unable to tumble become trapped within the agar matrix. Spontaneous mutations that restore spreading have been previously observed in the enteric bacterium Escherichia coli, and recent work in other bacterial species has isolated and quantified different classes of nonchemotacting mutants exhibiting the same spreading phenotype. We present a theoretical description of bacterial diffusion in a porous medium-the natural habitat for many cell types-which elucidates how diverse modifications of the motility apparatus resulting in a nonzero tumbling frequency allows for unjamming of otherwise straight-swimming cells at internal boundaries and leads to net migration. A unique result of our analysis is increasing diffusive spread with increasing tumbling frequency in the small pore limit, consistent with earlier experimental observations but not captured by previous models. Our theoretical results, combined with a simple model of bacterial diffusion and growth in agar, are compared with our experimental measurements of swim ring expansion as a function of time, demonstrating good quantitative agreement. Our results suggest that the details of the cellular tumbling process may be adapted to enable bacteria to propagate efficiently through complex environments. For engineered, self-propelled microswimmers that navigate via alternating straight runs and changes in direction, these results suggest an optimal reorientation strategy for efficient migration in a porous environment with a given microarchitecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.