ArticleBiophysical journal2016
Intracellular Impedance Measurements Reveal Non-ohmic Properties of the Extracellular Medium around Neurons.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Dopamine amplifies subthalamic long-latency responses to cortical stimulation in patients with Parkinson's disease.NPJ Parkinson's disease · 2026Article
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- Simulating epileptic seizures using the bidomain model.Scientific reports · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Extracellular and intracellular components of the impedance of neural tissue.Biophysical journal · 2022Article
- Conductance of porous media depends on external electric fields.Biophysical journal · 2021Article
- Recent advances in three-dimensional microelectrode array technologies for in vitro and in vivo cardiac and neuronal interfaces.Biosensors & bioelectronics · 2021Review
- Brain Waves: Emergence of Localized, Persistent, Weakly Evanescent Cortical Loops.Journal of cognitive neuroscience · 2020Article
- FEMfuns: A Volume Conduction Modeling Pipeline that Includes Resistive, Capacitive or Dispersive Tissue and Electrodes.Neuroinformatics · 2020Article
- Fast simulation of extracellular action potential signatures based on a morphological filtering approximation.Journal of computational neuroscience · 2020Article
- Article
- The Effect of Common Signals on Power, Coherence and Granger Causality: Theoretical Review, Simulations, and Empirical Analysis of Fruit Fly LFPs Data.Frontiers in systems neuroscience · 2018Article
- Is the Extracellular Impedance High and Non-resistive in Cerebral Cortex?Biophysical journal · 2017Article
- Analysis of Claims that the Brain Extracellular Impedance Is High and Non-resistive.Biophysical journal · 2017Article
- Magnitude and behavior of cross-talk effects in multichannel electrophysiology experiments.Journal of neurophysiology · 2017Article
- Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis.Journal of neurophysiology · 2017Article
- Collection of Simulated Data from a Thalamocortical Network Model.Neuroinformatics · 2017Article
- Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue.PLoS computational biology · 2016Article
- Local Field Potentials: Myths and Misunderstandings.Frontiers in neural circuits · 2016Review
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the electrical properties of the extracellular space around neurons is important for understanding the genesis of extracellular potentials, as well as for localizing neuronal activity from extracellular recordings. However, the exact nature of these extracellular properties is still uncertain. Here, we introduce a method to measure the impedance of the tissue, one that preserves the intact cell-medium interface using whole-cell patch-clamp recordings in vivo and in vitro. We find that neural tissue has marked non-ohmic and frequency-filtering properties, which are not consistent with a resistive (ohmic) medium, as often assumed. The amplitude and phase profiles of the measured impedance are consistent with the contribution of ionic diffusion. We also show that the impact of such frequency-filtering properties is possibly important on the genesis of local field potentials, as well as on the cable properties of neurons. These results show non-ohmic properties of the extracellular medium around neurons, and suggest that source estimation methods, as well as the cable properties of neurons, which all assume ohmic extracellular medium, may need to be reevaluated.
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