Evidence map›Paper›PMID 26745256›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Effect of Low Vitamin D on Volumetric Bone Mineral Density, Bone Microarchitecture, and Stiffness in Primary Hyperparathyroidism.

Marcella D Walker, Kyle K Nishiyama, Bin Zhou, Elaine Cong, Ji Wang, James A Lee, Anna Kepley, Chengchen Zhang, X Edward Guo, Shonni J Silverberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  6. Article
  7. Article
  8. Article
  9. [Differential diagnoses of osteoporosis].Zeitschrift fur Gerontologie und Geriatrie · 2019
    Review
  10. Article
  11. Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018
    Review
  12. Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
  13. Communicating Hydrocephalus in a Case of Long-Term Primary Hyperparathyroidism.Journal of the ASEAN Federation of Endocrine Societies · 2018
    Article
  14. Determinants of bone mineral density in young Australian women; results from the Safe-D study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  15. Skeletal effects of vitamin D deficiency among patients with primary hyperparathyroidism.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  16. Effect of concomitant vitamin D deficiency or insufficiency on lumbar spine volumetric bone mineral density and trabecular bone score in primary hyperparathyroidism.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marcella D WalkerDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Kyle K NishiyamaDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Bin ZhouDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Elaine CongDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Ji WangDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
James A LeeDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Anna KepleyDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Chengchen ZhangDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
X Edward GuoDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Shonni J SilverbergDepartment of Medicine (M.D.W., K.K.N., E.C., A.K., C.Z., S.J.S.), Columbia University, College of Physicians and Surgeons, New York, New York 10032; Bone Bioengineering Laboratory (B.Z., J.W., X.E.G.), Columbia University, New York, New York 10027; Department of Surgery (J.A.L.), Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Columbia University · US

Funding

Micro-Mechanical Modeling of Trabecular BoneR01AR051376 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD · 2006 to 2015
$3.2M
Vitamin D Deficiency in Primary HyperparathyroidismR01DK084986 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2010 to 2014
$3.0M
Non-Classical Manifestations of Primary HyperparathyroidismK24DK074457 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2006 to 2016
$1.7M
NIAMS NIH HHS R01 AR051376NIDDK NIH HHS K24 DK074457NIDDK NIH HHS R01 DK084986
6 · The paper itself

Abstract

contextPatients with 25-hydroxyvitamin D deficiency (25OHD <20 ng/ml) and primary hyperparathyroidism (PHPT) have more severe disease reflected by higher serum PTH levels compared to those with vitamin D levels in the insufficient (20-29 ng/ml) or replete range (≥ 30 ng/ml).

objectiveTo study the effect of low vitamin D in PHPT on volumetric bone mineral density (vBMD), bone microarchitecture, and bone strength. DESIGN, SETTING, AND

participantsThis is a cross-sectional analysis of 99 PHPT patients with and without 25OHD insufficiency and deficiency from a university hospital. OUTCOME MEASURES: Bone microarchitecture and strength were assessed with high-resolution peripheral quantitative computed tomography (HRpQCT), microfinite element analysis, and individual trabecula segmentation.

resultsIn this cohort, 25OHD levels were deficient in 18.1%, insufficient in 35.4% and replete in 46.5%. Those with lower 25OHD levels had higher PTH (P < .0001), were younger (P = .001) and tended to weigh more (P = .053). There were no age-, weight- and sex-adjusted between-group differences (<20 vs 20-29 vs ≥ 30 ng/ml) in any HRpQCT, microfinite element analysis, or individual trabecula segmentation indices. Because few participants had 25OHD below 20 ng/ml, we also compared those with 25OHD below 30 vs at least 30 ng/ml and found only a trend toward lower adjusted cortical vBMD (3.1%, P = .08) and higher cortical porosity (least squares mean ± SEM 7.5 ± 0.3 vs 6.6 ± 0.3%, P = .07) at the tibia but not the radius. Stiffness did not differ at either site. In multiple regression analysis, 25OHD accounted for only three of the 49.2% known variance in cortical vBMD; 25OHD was not significant in the model for cortical porosity at the tibia.

conclusionLow 25OHD levels are associated with higher PTH levels in PHPT, but contrary to our hypothesis, these differences did not significantly affect vBMD or microarchitecture, nor did they result in lower stiffness. Low vitamin D in PHPT using current 25OHD thresholds for insufficiency and deficiency did not significantly affect skeletal integrity as assessed by HRpQCT.

Indexed as

Bone DensityAgedBone and BonesCross-Sectional StudiesFemaleHumansHyperparathyroidism, PrimaryMaleMiddle AgedTomography, X-Ray ComputedVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID26745256
PMCPMC4803169
OpenAlexW2226490111

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.