Evidence map›Paper›PMID 26745186›Full record

ArticleeLife2016

Give it a REST!

Steven M Pollard, Maria Angeles Marques-Torrejon

Open access · goldAbstract readComment
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Steven M PollardMRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Maria Angeles Marques-TorrejonMRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
MRC Centre for Regenerative Medicine · GB

Funding

Cancer Research UK 17368Cancer Research UK 19680Cancer Research UK 21992
6 · The paper itself

Abstract

The REST protein helps to prevent the premature activation of genes that are only expressed in mature neurons, and is now found to protect the genome of neural progenitor cells.

Indexed as

Cell DifferentiationGenomeNeural Stem CellsNeurogenesisNeuronsRepressor ProteinsRepressor Proteinsdevelopmental biologygenomic instabilityknockout animalsmouseneurogenesisrepressionREST complexstem cellstranscription factors

Identifiers

PMID26745186
PMCPMC4744202
OpenAlexW2232178016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.