ArticleCurrent opinion in behavioral sciences2016
Nucleus Accumbens AMPA Receptor Trafficking Upregulated by Food Restriction: An Unintended Target for Drugs of Abuse and Forbidden Foods.
Article in Current opinion in behavioral sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.Nature communications · 2021Article
- The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa.Frontiers in psychiatry · 2021Article
- Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs.Current pharmaceutical design · 2020Article
- Impulsive choice does not predict binge-like eating in rats.Behavioural pharmacology · 2018Article
- Functional and structural plasticity contributing to obesity: roles for sex, diet, and individual susceptibility.Current opinion in behavioral sciences · 2018Article
- Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts.Neuropharmacology · 2018Review
- Neuropharmacology of compulsive eating.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Accumbens Mechanisms for Cued Sucrose Seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Interaction of chronic food restriction and methylphenidate in sensation seeking of rats.Psychopharmacology · 2017Article
- Pathological Overeating: Emerging Evidence for a Compulsivity Construct.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Assessment of the motivation to use artificial sweetener among individuals with an eating disorder.Appetite · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
There is a high rate of comorbidity between eating disorders and substance abuse, and specific evidence that weight-loss dieting can increase risk for binge pathology, rebound excessive weight gain, and initiation and relapse to drug abuse. The present overview discusses basic science findings indicating that chronic food restriction induces dopamine conservation, compensatory upregulation of D-1 dopamine receptor signaling, and synaptic incorporation of calcium-permeable glutamatergic AMPA receptors in nucleus accumbens. Evidence is presented which indicates that these neuroadaptations account for increased incentive effects of food, drugs, and associated environments during food restriction. In addition, these same neuroadaptations underlie upregulation of sucrose- and psychostimulant-induced trafficking of AMPA receptors to the nucleus accumbens postsynaptic density, which may be a mechanistic basis of enduring maladaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.