Evidence map›Paper›PMID 26744613›Full record

ArticleGastroenterology and hepatology from bed to bench2016

Study of regulatory promoter polymorphism (-248 G>A) of Bax gene in patients with gastric cancer in the northern provinces of Iran.

Seyedeh Habibeh Mirmajidi, Mojtaba Najafi, Seyedeh Tahereh Mirmajidi, Nafiseh Nasri Nasrabadi

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. In Silico and Wet Analysis ofCurrent issues in molecular biology · 2025
    Article
  3. The Role of Functional Polymorphisms of ApoptoticIranian journal of medical sciences · 2025
    Article
  4. Article
  5. Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020
    Review
  6. Article
  7. Oncology research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Seyedeh Habibeh MirmajidiCollege of Sciences Sari Agricultural Sciences and Natural Resources University, Sari, Iran.
Mojtaba NajafiDepartment of Animal Sciences and Fisheries, Sari Agricultural Sciences and Natural Resources University, Iran.
Seyedeh Tahereh MirmajidiTehran University of Medical Sciences, Cancer Institute, Tehran, Iran.
Nafiseh Nasri NasrabadiStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer.

backgroundGastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of Bcl2 lead to cancer. PATIENTS AND

methodsBlood samples were collected from 100 cases and 89 controls in the northern provinces of Iran to evaluate promoter polymorphism (-248G<A) of Bax gene. Genotyping was carried out by PCR-RFLP method.

resultsThe result of this study demonstrated the existence of polymorphism in the above-mentioned region of Bax gene. Sixty-nine patients (%69) with genotype GG and 31 patients (%31) with genotype AG were observed in the case group. No mutant genotype was found among cases. Sixty-seven individuals (%75/28) with genotype GG, 21 individuals (%23/59) with genotype AG and only one mutant genotype (AA) were demonstrated in the control group. The bioinformatics analysis showed that this polymorphism removed the probable Sp1 motifs, which may affect its expression in the cells.

conclusionAllele G was the most frequent between both patient and control samples. Polymorphism may be effective on Bax expression, but it requires further investigation. Our results showed significant effects between genotypes and features of gender and age, whereas no significant relation were observed between the genotypes and grade, stage as well as smoking traits.

Indexed as

Bax geneGastric cancerPCR-RFLPPolymorphismPromoter

Identifiers

PMID26744613
PMCPMC4702040
OpenAlexW2181684841

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.