ArticleDrug discovery today. Disease models2015
MATHEMATICAL MODELING OF VENTILATION DEFECTS IN ASTHMA.
Article in Drug discovery today. Disease models, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Self-organized ventilation defects in asthma: insights and open-source implementation of the Venegas-Winkler model.Royal Society open science · 2026Article
- Identifying critical transitions in complex diseases.Journal of biosciences · 2022Review
- Inspiratory Efforts, Positive End-Expiratory Pressure, and External Resistances Influence Intraparenchymal Gas Redistribution in Mechanically Ventilated Injured Lungs.Frontiers in physiology · 2020Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The spatial pattern of methacholine bronchoconstriction recurs when supine independently of posture during provocation but does not recur between postures.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Airway narrowing by smooth muscle constriction is a hallmark of asthma attacks that may cause severe difficulties of breathing. However, the causes of asthma and the underlying mechanisms are not fully understood. Bronchoconstriction within a bronchial tree involves complex interactions among the airways that lead to the emergence of regions of poor ventilation (ventilation defects, VDefs) in the lungs. The emphasis of this review is on mathematical modeling of the mechanisms involved in bronchoconstriction and the emergence of the complex airway behavior that leads to VDefs. Additionally, the review discusses characteristic model behaviors and experimental data to demonstrate advances and limitations of different models.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.