Evidence map›Paper›PMID 26744538›Full record

ArticleBMJ case reports2016

Pathophysiology of tumour-induced microangiopathic haemolytic anaemia.

Pavani Chalasani, Jennifer M Segar, Marilyn Marron, Alison Stopeck

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Microangiopathic Haemolytic Anaemia in Metastatic Angiosarcoma: A Grave Marker of Bone Marrow Infiltration.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pavani ChalasaniUniversity of Arizona Cancer Center, Tucson, Arizona, USA.ORCID http://orcid.org/0000-0002-7953-2979
Jennifer M SegarDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Marilyn MarronUniversity of Arizona Cancer Center, Tucson, Arizona, USA.
Alison StopeckStonybrook, Stony Brook, New York, USA.
University of Arizona · USStony Brook Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombs-negative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CA-MAHA.

Indexed as

AgedAnemia, HemolyticAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCarcinoma, LobularCell-Derived MicroparticlesCyclophosphamideDoxorubicinFemaleHumansNeoplastic Cells, CirculatingParaneoplastic SyndromesThrombocytopeniaCyclophosphamideDoxorubicin

Identifiers

PMID26744538
PMCPMC4716353
OpenAlexW2228137217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.