ArticleThe Plant cell2016
The Arabidopsis NRG2 Protein Mediates Nitrate Signaling and Interacts with and Regulates Key Nitrate Regulators.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 185 citations in OpenAlex.
- A Restricted Two-Stage Multi-Locus Multi-Allele Genome-Wide Association Study Reveals Genomic Loci and Candidate Genes Controlling Plant-Height-Related Traits in Soybean Under Normal and Shade Conditions.International journal of molecular sciences · 2026Article
- Genome-wide analyses of NPF and NRT2 reveal a potential role for a key gene, CqNRT2.2, in the quinoa response to nitrate.BMC plant biology · 2026Article
- Transcriptome assemblies for two drug-type cannabis chemotypes by long-read RNA sequencing.The plant genome · 2026Article
- Evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered nitrate signaling regulatory network in plant roots.BMC plant biology · 2025Article
- Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis.BMC plant biology · 2025Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2025Article
- Sink strength, nutrient allocation, cannabinoid yield, and associated transcript profiles vary in two drug-type Cannabis chemovars.Journal of experimental botany · 2025Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2024Article
- NIN-LIKE PROTEIN3.2 inhibits repressor Aux/IAA14 expression and enhances root biomass in maize seedlings under low nitrogen.The Plant cell · 2024Article
- NIN-like proteins (NLPs) as crucial nitrate sensors: an overview of their roles in nitrogen signaling, symbiosis, abiotic stress, and beyond.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Transcriptome Profiling Reveals the Gene Network Responding to Low Nitrogen Stress in Wheat.Plants (Basel, Switzerland) · 2024Article
- The Genetic Dissection of Nitrogen Use-Related Traits in Flax (International journal of molecular sciences · 2023Article
- Finding Balance in Adversity: Nitrate Signaling as the Key to Plant Growth, Resilience, and Stress Response.International journal of molecular sciences · 2023Review
- An Integrated Analysis of Metabolome, Transcriptome, and Physiology Revealed the Molecular and Physiological Response ofPlants (Basel, Switzerland) · 2023Article
- Gene Expression, Enzyme Activity, Nitrogen Use Efficiency, and Yield of Rice Affected by Controlled-Release Nitrogen.ACS omega · 2023Article
- The small peptide CEP1 and the NIN-like protein NLP1 regulate NRT2.1 to mediate root nodule formation across nitrate concentrations.The Plant cell · 2023Article
- Transcriptome Profiling and Chlorophyll Metabolic Pathway Analysis Reveal the Response ofPlants (Basel, Switzerland) · 2023Article
- Article
- An integrated nitrogen utilization gene network and transcriptome analysis reveal candidate genes in response to nitrogen deficiency inFrontiers in plant science · 2023Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show that NITRATE REGULATORY GENE2 (NRG2), which we identified using forward genetics, mediates nitrate signaling in Arabidopsis thaliana. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). Genetic and molecular data suggest that NRG2 functions upstream of NRT1.1 in nitrate signaling. Furthermore, NRG2 directly interacts with the nitrate regulator NLP7 in the nucleus, but nuclear retention of NLP7 in response to nitrate is not dependent on NRG2. Transcriptomic analysis revealed that genes involved in four nitrogen-related clusters including nitrate transport and response to nitrate were differentially expressed in the nrg2 mutants. A nitrogen compound transport cluster containing some members of the NRT/PTR family was regulated by both NRG2 and NRT1.1, while no nitrogen-related clusters showed regulation by both NRG2 and NLP7. Thus, NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.