ArticleJournal of neuro-oncology2016
Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation.
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 87 citations in OpenAlex.
- Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.Neuro-oncology · 2022Trial
- Long-term intelligence after high-dose radiotherapy to the primary site versus chemotherapy and whole-ventricle radiotherapy in patients with germinoma.International journal of clinical oncology · 2026Article
- The influence of tumor location on the onset of endocrine deficits in pediatric brain tumor survivors.Translational cancer research · 2025Article
- Old Tools in a New Era: The Continued Relevance of Chemotherapy in Pediatric Neuro-Oncology.Current oncology (Toronto, Ont.) · 2025Review
- Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up.Journal of neuro-oncology · 2024Article
- Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities.Neuro-oncology · 2024Article
- Pineal/germ cell tumors and pineal parenchymal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study.Journal of neuro-oncology · 2023Article
- Time to dismiss boost? Outcomes of children with localized and metastatic germinoma.Journal of neuro-oncology · 2023Article
- Outcome of Children and Adolescents With Primary Intracranial Germinoma Treated With Chemotherapy and Reduced Dose-Field Irradiation: A Prospective Brazilian Experience.JCO global oncology · 2023Article
- Excluding prepontine cistern from whole ventricle radiotherapy target volume in localized germinoma.Radiation oncology journal · 2023Article
- Proton therapy for pediatric diencephalic tumors.Frontiers in oncology · 2023Review
- Photon versus proton whole ventricular radiotherapy for non-germinomatous germ cell tumors: A report from the Children's Oncology Group.Pediatric blood & cancer · 2022Article
- Review
- EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.Neuro-oncology · 2022Article
- Bifocal lesions have a poorer treatment outcome than a single lesion in adult patients with intracranial germinoma.PloS one · 2022Article
- Pituitary Stalk Germ Cell Tumors: Retrospective Case Series and Literature Review.International journal of endocrinology · 2022Article
- Advances in Molecular Profiling and Developing Clinical Trials of CNS Germ Cell Tumors: Present and Future Directions.Current oncology reports · 2022Review
- Characteristics of growth disturbances in patients with intracranial germinomas of different origins.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma.Journal of personalized medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CNS germinomas have an excellent prognosis with radiation therapy alone. However, in children, volume and dose of CNS radiation are associated with neurocognitive and neuroendocrine sequelae. Our objective was to determine long-term outcomes of our cohort who received chemotherapy and reduced radiation. This retrospective cohort study analyzed treatment and outcome of intracranial germinoma patients consecutively treated at Sick Kids, Toronto, Canada, from January 2000 to December 2013. 24 children (13 male, 11 female; median age 13.36 years) were identified. Median follow up was 61 months (range 1-144 months). Tumor location was suprasellar (n = 9), bifocal (8), pineal (6), and basal ganglia (1). Three children showed dissemination on imaging. 2/24 had only elevated serum human chorionic gonadotropin, 3/24 only elevated lumbar cerebrospinal fluid (CSF) hCG, and 2/24 had both elevated serum and lumbar CSF hCG. 23/24 children completed treatment and received multi-agent chemotherapy followed by either ventricular radiation (2340-2400 cGy) (n = 9), ventricular radiation + boost (1600 cGy) (n = 8), whole brain (2340 cGy) (n = 3), focal (4000 cGy) (n = 2) or craniospinal radiation (2340 cGy) (n = 1). Five-year progression free and overall survival was 96 and 100 % respectively. 8/24 patients with ventricular radiation ± boost (2340/4000 cGy) displayed stable full scale intelligence quotient over a mean interval of 3 years following radiation, but showed declined processing speed. In this limited experience, excellent 5-year overall survival rates were achieved with chemotherapy followed by reduced whole ventricular radiation even if ventricular radiation was delivered without boost.
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