ArticleMetabolic brain disease2016
Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.
Article in Metabolic brain disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Differential Effects of Human P301L Tau Expression in Young versus Aged Mice.International journal of molecular sciences · 2021Article
- Recent Progress in the Pharmacotherapy of Alzheimer's Disease.Drugs & aging · 2017Review
- Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.Alzheimer's research & therapy · 2017Article
- Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus.Neural plasticity · 2017Review
- Review
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Those at risk for Alzheimer's disease (AD) often exhibit hippocampal hyperexcitability in the years preceding diagnosis. Our previous work with the rTg(TauP301L)4510 tau mouse model of AD suggests that this increase in hyperexcitability is likely mediated by an increase in depolarization-evoked glutamate release and a decrease in glutamate uptake, alterations of which correlate with learning and memory deficits. Treatment with riluzole restored glutamate regulation and rescued memory deficits in the TauP301L model. Here, we used enzyme-based ceramic microelectrode array technology to measure real-time phasic glutamate release and uptake events in the hippocampal subregions of TauP301L mice. For the first time, we demonstrate that perturbations in glutamate transients (rapid, spontaneous bursts of glutamate) exist in a tau mouse model of AD mouse model and that riluzole mitigates these alterations. These results help to inform our understanding of how glutamate signaling is altered in the disease process and also suggest that riluzole may serve as a clinically applicable therapeutic approach in AD.
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Registered trials
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