Evidence map›Paper›PMID 26743822›Full record

ArticleNature communications2016

Repetitive magnetic stimulation induces plasticity of inhibitory synapses.

Maximilian Lenz, Christos Galanis, Florian Müller-Dahlhaus, Alexander Opitz, Corette J Wierenga, Gábor Szabó, Ulf Ziemann, Thomas Deller, Klaus Funke, Andreas Vlachos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maximilian LenzInstitute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University, Frankfurt/Main 60590, Germany.
Christos GalanisInstitute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University, Frankfurt/Main 60590, Germany.
Florian Müller-DahlhausDepartment of Neurology and Stroke and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University, Tübingen 72076, Germany.
Alexander OpitzCenter for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
Corette J WierengaDivision of Cell Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, The Netherlands.
Gábor SzabóLaboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Budapest H1083, Hungary.
Ulf ZiemannDepartment of Neurology and Stroke and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University, Tübingen 72076, Germany.
Thomas DellerInstitute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University, Frankfurt/Main 60590, Germany.
Klaus FunkeDepartment of Neurophysiology, Medical Faculty, Ruhr-University, Bochum 44780, Germany.
Andreas VlachosInstitute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University, Frankfurt/Main 60590, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic tool in neurology and psychiatry. While repetitive magnetic stimulation (rMS) has been shown to induce plasticity of excitatory synapses, it is unclear whether rMS can also modify structural and functional properties of inhibitory inputs. Here we employed 10-Hz rMS of entorhinohippocampal slice cultures to study plasticity of inhibitory neurotransmission on CA1 pyramidal neurons. Our experiments reveal a rMS-induced reduction in GABAergic synaptic strength (2-4 h after stimulation), which is Ca(2+)-dependent and accompanied by the remodelling of postsynaptic gephyrin scaffolds. Furthermore, we present evidence that 10-Hz rMS predominantly acts on dendritic, but not somatic inhibition. Consistent with this finding, a reduction in clustered gephyrin is detected in CA1 stratum radiatum of rTMS-treated anaesthetized mice. These results disclose that rTMS induces coordinated Ca(2+)-dependent structural and functional changes of specific inhibitory postsynapses on principal neurons.

Indexed as

Magnetic FieldsNeural InhibitionNeuronal PlasticityTranscranial Direct Current StimulationAnimalsBlotting, WesternCA1 Region, HippocampalCalciumCarrier ProteinsCell BodyDendritesFluorescence Recovery After PhotobleachingGABAergic Neuronsgamma-Aminobutyric AcidImmunohistochemistryIn Vitro TechniquesCalciumCarrier Proteinsgamma-Aminobutyric AcidgephyrinMembrane Proteins

Identifiers

PMID26743822
PMCPMC4729863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.