ArticleScientific reports2016
A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 77 citations in OpenAlex.
- 1,8-Naphthalimide: A Versatile Platform for the Design of Fluorescent Probes Targeting Hydrogen Sulfide in Biological Systems.Molecules (Basel, Switzerland) · 2026Review
- Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals.Bioconjugate chemistry · 2026Review
- Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species.Chemical reviews · 2024Review
- Advances and Opportunities in HJACS Au · 2023Review
- Activity-Based Fluorescent Probes Based on Hemicyanine for Biomedical Sensing.Molecules (Basel, Switzerland) · 2022Review
- Masked Amino Trimethyl Lock (HChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- A naphthalimide-based peptide conjugate for concurrent imaging and apoptosis induction in cancer cells by utilizing endogenous hydrogen sulfide.Chemical science · 2021Article
- Real-time imaging of senescence in tumors with DNA damage.Scientific reports · 2019Article
- Article
- Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.Scientific reports · 2017Article
- A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells.Scientific reports · 2017Article
- Novel Fluorescence Arginine Analogue as a Sensor for Direct Identification and Imaging of Nitric Oxide Synthase-like Enzymes in Plants.Scientific reports · 2016Article
- A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective and Sensitive Detection of H2S: Synthesis, Spectra and Bioimaging.Scientific reports · 2016Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulphide (H2S), the third endogenous gaseous signalling molecule, has attracted attention in biochemical research. The selective detection of H2S in living systems is essential for studying its functions. Fluorescence detection methods have become useful tools to explore the physiological roles of H2S because of their real-time and non-destructive characteristics. Herein we report a near-infrared fluorescent probe, NIR-HS, capable of tracking H2S in living organisms. With high sensitivity, good selectivity and low cytotoxicity, NIR-HS was able to recognize both the exogenous and endogenous H2S in living cells. More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine β-synthase (CBS), one of the enzymes responsible for producing endogenous H2S. The probe was also successfully applied to detect both the exogenous and endogenous H2S in living mice. The superior sensing properties of the probe render it a valuable research tool in the H2S-related medical research.
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