ArticleVeterinary research2016
The non-structural protein μNS of piscine orthoreovirus (PRV) forms viral factory-like structures.
Article in Veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Toward Effective Vaccines Against Piscine Orthoreovirus: Challenges and Current Strategies.Viruses · 2025Review
- Analyses and Insights into Genetic Reassortment and Natural Selection as Key Drivers ofViruses · 2024Article
- Transcriptomics of early responses to purifiedFrontiers in immunology · 2024Article
- Transcriptomic analysis reveals impact of gE/gI/TK deletions on host response to PRV infection.Virology journal · 2023Article
- Dissemination ofPathogens (Basel, Switzerland) · 2020Article
- Evolution of theViruses · 2019Article
- Detection of Salmonid IgM Specific to theFrontiers in immunology · 2019Article
- Molecular and Antigenic Characterization of Piscine orthoreovirus (PRV) from Rainbow Trout (Oncorhynchus mykiss).Viruses · 2018Article
- Antiviral Responses and Biological Concequences ofFrontiers in immunology · 2018Review
- Article
- Viral Protein Kinetics of Piscine Orthoreovirus Infection in Atlantic Salmon Blood Cells.Viruses · 2017Article
- Virus-mediated suppression of host non-self recognition facilitates horizontal transmission of heterologous viruses.PLoS pathogens · 2017Article
- Infection experiments with novel Piscine orthoreovirus from rainbow trout (Oncorhynchus mykiss) in salmonids.PloS one · 2017Article
- Piscine orthoreovirus (PRV) in red and melanised foci in white muscle of Atlantic salmon (Salmo salar).Veterinary research · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Piscine orthoreovirus (PRV) is associated with heart- and skeletal muscle inflammation in farmed Atlantic salmon. The virus is ubiquitous and found in both farmed and wild salmonid fish. It belongs to the family Reoviridae, closely related to the genus Orthoreovirus. The PRV genome comprises ten double-stranded RNA segments encoding at least eight structural and two non-structural proteins. Erythrocytes are the major target cells for PRV. Infected erythrocytes contain globular inclusions resembling viral factories; the putative site of viral replication. For the mammalian reovirus (MRV), the non-structural protein μNS is the primary organizer in factory formation. The analogous PRV protein was the focus of the present study. The subcellular location of PRV μNS and its co-localization with the PRV σNS, µ2 and λ1 proteins was investigated. We demonstrated that PRV μNS forms dense globular cytoplasmic inclusions in transfected fish cells, resembling the viral factories of MRV. In co-transfection experiments with μNS, the σNS, μ2 and λ1 proteins were recruited to the globular structures. The ability of μNS to recruit other PRV proteins into globular inclusions indicates that it is the main viral protein involved in viral factory formation and pivotal in early steps of viral assembly.
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