ReviewParasitology2016
Plasmodium malaria and antimalarial antibodies in the first year of life.
Review in Parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 103 citations in OpenAlex.
- The Impact of Maternal Depression and Parent-Child Interactions on Risk of Parasitic Infections in Early Childhood: A Prospective Cohort in Benin.Maternal and child health journal · 2022Trial
- Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children.Malaria journal · 2018Trial
- Mother-Newborn Pairs in Malawi Have Similar Antibody Repertoires to Diverse Malaria Antigens.Clinical and vaccine immunology : CVI · 2017Trial
- Clinical malaria recurrence and associated factors in infancy following IPTp-DP versus IPTp-SP in Busia, Uganda; a secondary analysis using the Conditional Frailty model.Malaria journal · 2026Article
- Pediatric malaria in a non-endemic European setting: clinical patterns, laboratory markers, and the ambiguous role of immunity.Infection · 2026Article
- Natural History and the Burden of Malaria During the First Year of Life in the High-Transmission Setting of Uganda.The American journal of tropical medicine and hygiene · 2026Article
- Malaria in children aged <6 months: a narrative review of current evidence, recommendations and practice gaps.Tropical medicine and health · 2026Review
- An age-structured mathematical model to assess the combined effects of vaccine and non-vaccine interventions on malaria transmission and burden.Infectious Disease Modelling · 2026Article
- IgG and IgM responses to PfEMP1 domains associated with semi-immunity to clinical malaria in Burkinabe children under five.Frontiers in immunology · 2026Article
- Epidemiology of Plasmodium spp. Detection Among Acute Febrile Illness Patients in Two Regions of Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Prevalence of malaria and associated risk factors among febrile under-five refugee children attending Panyadoli Health Centre III, Kiryandongo District, Mid-western Uganda.Malaria journal · 2025Article
- Choice of Drug for Malaria Prevention During Pregnancy Does Not Affect Infant Serologic Responses toOpen forum infectious diseases · 2025Article
- Factors associated with malaria infection in under-5 children in Papua Province, Indonesia: an observational study.Osong public health and research perspectives · 2024Article
- Monoclonal antibodies to the circumsporozoite proteins as an emerging tool for malaria prevention.Nature immunology · 2024Review
- Mature beyond their years: young children who escape detection of parasitemia despite living in settings of intense malaria transmission.Biochemical Society transactions · 2024Review
- TargetingiScience · 2024Article
- Antiplasmodial Activity of ProbioticJournal of tropical medicine · 2024Article
- One hundred malaria attacks since birth. A longitudinal study of African children and young adults exposed to high malaria transmission.EClinicalMedicine · 2024Article
- Age-specific malaria vulnerability and transmission reservoir among children.Global pediatrics · 2023Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Malaria is one of the most serious infectious diseases with most of the severe disease caused by Plasmodium falciparum (Pf). Naturally acquired immunity develops over time after repeated infections and the development of antimalarial antibodies is thought to play a crucial role. Neonates and young infants are relatively protected from symptomatic malaria through mechanisms that are poorly understood. The prevailing paradigm is that maternal antimalarial antibodies transferred to the fetus in the last trimester of pregnancy protect the infant from early infections. These antimalarial antibodies wane by approximately 6 months of age leaving the infant vulnerable to malaria, however direct evidence supporting this epidemiologically based paradigm is lacking. As infants are the target population for future malaria vaccines, understanding how they begin to develop immunity to malaria and the gaps in their responses is key. This review summarizes the antimalarial antibody responses detected in infants and how they change over time. We focus primarily on Pf antibody responses and will briefly mention Plasmodium vivax responses in infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.